Archive for March, 2008
Control mundial de la tuberculosis 2008
RESULTADOS PRINCIPALES
La carga mundial de la tuberculosis
Nota completa
http://www.who.int/tb/publications/global_report/2008/key_points/es/index.html
Add comment March 29, 2008
Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study
The Lancet March 29 – April 4, 2008 V.371 N.9618 p.1108-1113
Articles
Anne von Gottberg, Keith P Klugman, Cheryl Cohen, Nicole Wolter, Linda de Gouveia, Mignon du Plessis, Ruth Mpembe, Vanessa Quan, Andrew Whitelaw, Rena Hoffmann, Nelesh Govender, Susan Meiring, Anthony M Smith, Stephanie Schrag, for the Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA)
abstract
http://www.thelancet.com/journals/lancet/article/PIIS0140673608603505/abstract
Add comment March 28, 2008
Crystalluria from Acyclovir Use
N. Engl J Medicine Mar 27, 2008 V.358 N.13 e14
Images in Clinical Medicine
FREE Full Text (CLIC en PDF)
http://content.nejm.org/cgi/content/full/358/13/e14?query=TOC
Add comment March 27, 2008
C-Reactive Protein Is an Independent Predictor of Severity in Community-acquired Pneumonia
The American Journal of Medicine Mar 2008 V.121 N.3 p.219-225
Abstract
Background
C-reactive protein (CRP) is an acute phase protein synthesized by the liver primarily in response to interleukin-6. Initial studies have suggested that inflammatory markers may have a role in predicting severity. We investigated whether admission and day 4 CRP could predict severity in community-acquired pneumonia.
Methods
A prospective study was carried out over a 2-year period in a large teaching hospital. CRP was measured on admission and on day 4. The outcomes of interest were: 30-day mortality; need for mechanical ventilation and/or inotropic support; development of complicated pneumonia (lung abscess, empyema, or complicated parapneumonic effusion); the value of predictive tests were assessed using multivariate logistic regression.
Results
There were 570 patients included in the study; 30-day mortality was 9.6%. Low CRP levels showed a high negative predictive value for excluding 30-day mortality (CRP <10 mg/L=100%, CRP <50=99.1%, CRP <100=98.9%, CRP <200=94.9%). Low admission CRP levels <100 mg/L were independently associated with reduced 30-day mortality (odds ratio [OR] 0.18; 0.04-0.85), P=.03; need for mechanical ventilation and/or inotropic support (OR 0.21; 0.14-0.4), P=.002; and complicated pneumonia (OR 0.05; 0.01-0.35), P=.003.
A CRP that fails to fall by 50% or more within 4 days of admission is independently associated with increased 30 day mortality (OR 24.5; 6.4-93.4), P <.0001; need for mechanical ventilation and/or inotropic support (OR 7.1; 2.8-17.8), P <.0001 and complicated pneumonia (OR 15.4; 6.32-37.6), P <.0001.
Conclusions
Admission CRP <100 mg/L has reduced risk for 30-day mortality, need for mechanical ventilation and/or inotropic support, and complicated pneumonia. Failure of CRP to fall by 50% or more at day 4 leads to an increased risk for 30-day mortality, need for mechanical ventilation and/or inotropic support, and complicated pneumonia. C-reactive protein is an independent marker of severity in community-acquired pneumonia.
abstract
http://www.amjmed.com/article/S0002-9343(07)01180-1/fulltext
FREE Full Text (CLIC en full text PDF) o directamente en el siguiente link:
http://download.journals.elsevierhealth.com/pdfs/journals/0002-9343/PIIS0002934307011801.pdf
Add comment March 27, 2008
Infectious syphilis in high-income settings in the 21st century
The Lancet Infectious Diseases Mar 2008 V.8 p.244-253
Review
Kevin A Fenton MD b , Romulus Breban PhD c, Raffaele Vardavas PhD d, Justin T Okano MS d, Tara Martin e, Sevgi Aral PhD a and Prof Sally Blower PhD d
abstract
http://www.thelancet.com/journals/laninf/article/PIIS1473309908700653/abstract
Add comment March 27, 2008
Neuroinvasion by Mycoplasma pneumoniae in Acute Disseminated Encephalomyelitis
Emerging Infectious Diseases Journal April 2008 V.14 N.4
Bernhard Stamm,* Michael Moschopulos,* Hansjoerg Hungerbuehler,* Jeannette Guarner,† Gillian L. Genrich,† and Sherif R. Zaki†
*Kantonsspital Aarau, Aarau, Switzerland; and †Centers for Disease Control and Prevention, Atlanta, Georgia, USA
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http://www.cdc.gov:80/eid/content/14/4/641.htm?s_cid=eid641_e
Add comment March 27, 2008
Chagas Disease, France
Emerging Infectious Diseases Journal April 2008 V.14 N.4
François-Xavier Lescure,* Ana Canestri,† Hugues Melliez,‡ Stéphane Jauréguiberry,* Michel Develoux,* Richard Dorent,* Jean-Baptiste Guiard-Schmid,* Philippe Bonnard,* Faïza Ajana,‡ Valeria Rolla,§ Yves Carlier,¶ Frederick Gay,†Marie-Hélène Elghouzzi,# Martin Danis,† and Gilles Pialoux*
*Hôpital Tenon AP-HP, Paris, France; †Hôpital La Pitié Salpétrière AP-HP, Paris, France; ‡Le Centre Hospitalier de Tourcoing, Tourcoing, France; §Instituto de Pesquisa Clinica Evandro Chagas – Fiocruz, Rio de Janeiro, Brazil; ¶Université libre de Bruxelles, Brussels, Belgium; and #Etablissement Français du Sang d’lle de France, Paris, France
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http://www.cdc.gov:80/eid/content/14/4/644.htm?s_cid=eid644_e
Add comment March 27, 2008
Dengue Virus Type 4, Manaus, Brazil
Emerging Infectious Diseases Journal April 2008 V.14 N.4
Regina Maria Pinto de Figueiredo,*1 Felipe Gomes Naveca,†1 Michele de Souza Bastos,*1 Miriam do Nascimento Melo,* Suziane de Souza Viana,‡ Maria Paula Gomes Mourão,* Cristóvão Alves Costa,‡ and Izeni Pires Farias§
*Fundação de Medicina Tropical do Amazonas, Manaus, Brazil; †Fundação Alfredo da Matta, Manaus, Brazil; ‡Instituto Nacional de Pesquisas da Amazônia, Manaus, Brazil; and §Universidade Federal do Amazonas, Manaus, Brazil
FREE Full Text (CLIC en Download this article as PDF)
http://www.cdc.gov:80/eid/content/14/4/667.htm?s_cid=eid667_e
Add comment March 27, 2008
Antimicrobial-Resistant Pathogens in Intensive Care Units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) Study, 2005-2006
Antimicrobial Agents and Chemotherapy 1 Apr 2008 V.52 N.4 p.1430-1437
George G. Zhanel,1,2,3* Mel DeCorby,1,3 Nancy Laing,1,3 Barb Weshnoweski,3 Ravi Vashisht,1,3 Franil Tailor,3 Kim A. Nichol,3 Aleksandra Wierzbowski,1,3 Patricia J. Baudry,1,3 James A. Karlowsky,1,3 Philippe Lagacé-Wiens,1,3 Andrew Walkty,1,3 Melissa McCracken,4 Michael R. Mulvey,4 Jack Johnson,5
The Canadian Antimicrobial Resistance Alliance (CARA), and Daryl J. Hoban1,3 Department of Medical Microbiology, Faculty of Medicine, University of Manitoba,1 Departments of Medicine,2 Clinical Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada,3 Nosocomial Infections Branch, National Microbiology Laboratory, Winnipeg, Manitoba, Canada,4 International Health Management Associates, Chicago, Illinois5
Add comment March 27, 2008
Antibiotic Susceptibility of Invasive Haemophilus influenzae Strains in Canada
Antimicrobial Agents and Chemotherapy 1 Apr 2008 V.52 N.4 p.1551-1552
Michelle L. Sill and Raymond S. W. Tsang*
Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Add comment March 27, 2008
