Respiratory Virus Infection During Pregnancy: Does It Matter?

The Journal of Infectious Diseases August 15, 2018 V.218 N.4 P.512-515

EDITOR’S CHOICE

Janet A Englund; Helen Y Chu

FULL TEXT

https://academic.oup.com/jid/article/218/4/512/4993270

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August 13, 2018 at 6:24 pm

Increases in Human Papillomavirus Vaccination Among Adolescent and Young Adult Males in the United States, 2011–2016

The Journal of Infectious Diseases July 1, 2018 V.218 N.1 P.109-113

EDITOR’S CHOICE

Eshan U Patel; M Kate Grabowski; Anna L Eisenberg; Zoe R Packman; Patti E Gravitt

Temporal trends in human papillomavirus vaccine coverage were assessed among 2011–2016 National Health and Nutrition Examination Surveys participants aged 9–26 years. Coverage substantially increased among males, but minimal gains were observed among females. Coverage remains below national targets.

FULL TEXT

https://academic.oup.com/jid/article/218/1/109/4951824

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August 13, 2018 at 6:21 pm

Risk of HPV-16/18 Infections and Associated Cervical Abnormalities in Women Seropositive for Naturally Acquired Antibodies: Pooled Analysis Based on Control Arms of Two Large Clinical Trials

The Journal of Infectious Diseases July 1, 2018 V.218 N.1 P.84-94

Mahboobeh Safaeian; Xavier Castellsagué; Allan Hildesheim; Sholom Wacholder; Mark H Schiffman

Using data from PATRICIA and Costa Rica Vaccine trials, the risk of detecting a new HPV-18 infection and associated lesions was compared between women HPV seropositive and seronegative at enrollment. High HPV-18 naturally acquired antibodies were associated with partial protection.

FULL TEXT

https://academic.oup.com/jid/article/218/1/84/4990620

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August 13, 2018 at 6:19 pm

Increased Risk of HIV Acquisition Among Women Throughout Pregnancy and During the Postpartum Period: A Prospective Per-Coital-Act Analysis Among Women With HIV-Infected Partners

The Journal of Infectious Diseases July 1, 2018 V.218 N.1 P.16-25

EDITOR’S CHOICE

Kerry A Thomson; James Hughes; Jared M Baeten; Grace John-Stewart; Connie Celum

The risk of human immunodeficiency virus type 1 (HIV-1) acquisition by women per condomless sex act was 3-fold and 4-fold higher during late pregnancy and the postpartum period, respectively, relative to the nonpregnant period. Enhanced HIV-1 prevention and testing strategies are needed during pregnancy and the postpartum period.

FULL TEXT

https://academic.oup.com/jid/article/218/1/16/4915924

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August 13, 2018 at 6:16 pm

Risk of HIV Acquisition During Pregnancy and Postpartum: A Call for Action

The Journal of Infectious Diseases July 1, 2018 V.218 N.1 P.1-4

EDITOR’S CHOICE

Lynne M Mofenson

Prospective studies exploring the relationship between pregnancy and HIV acquisition in women have had inconsistent results, with some studies documenting an increased risk [1–3], while others finding no increase in risk — or even lower risk — after controlling for sexual behavior and other confounding factors such as sexually transmitted infections [4–7]. A meta-analysis of 19 cohort studies estimated a pooled HIV incidence during pregnancy and postpartum of 3.9 per 100 person-years (4.7 per 100 person-years during pregnancy and 2.9 per 100 person-years postpartum) [8], similar to that defined as “substantial risk” in nonpregnant individuals, such as female sex workers, by the World Health Organization (WHO) [9]. The pooled meta-analysis reported that HIV incidence was not significantly higher among pregnant or postpartum women than among nonpregnant/nonpostpartum women, but only 5 studies had appropriate data and were not able to control for a variety of confounding factors, limiting the power to detect associations…

FULL TEXT

https://academic.oup.com/jid/article/218/1/1/4913312

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August 13, 2018 at 6:15 pm

Prophylactic Antimicrobial Therapy for Acute Aspiration Pneumonitis

Clinical Infectious Diseases August 15, 2018 V.67 N.4 P.513-518

EDITOR’S CHOICE

Vlad Dragan; Yanliang Wei; Marion Elligsen; Alex Kiss; Sandra A N Walker

In a cohort of patients with acute aspiration pneumonitis, antibiotics within 48 hours of macroaspiration was not associated with reduced mortality compared to supportive care only, yet resulted in the need for more frequent antibiotic escalation and fewer antibiotic-free days.

FULL TEXT

https://academic.oup.com/cid/article/67/4/513/4846855

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August 12, 2018 at 8:17 pm

Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation

Clinical Infectious Diseases August 15, 2018 V.67 N.4 P.505-512

Stephanie N Taylor; David H Morris; Ann K Avery; Kimberly A Workowski; Byron E Batteiger

In this phase 2 study, single oral doses of gepotidacin were ≥95% effective for bacterial eradication in culture-proven uncomplicated urogenital gonorrhea. New antibiotics for drug-resistant Neisseria gonorrhoeae are urgently needed. With additional evaluation, gepotidacin may provide an alternative therapeutic option.

FULL TEXT

https://academic.oup.com/cid/article/67/4/504/4958398

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August 12, 2018 at 8:16 pm

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