Clinical Evaluation of Macrolide-Resistant Mycoplasma pneumoniae

January 26, 2006 at 11:11 am Leave a comment

Source: Antimicrobial Agents and Chemotherapy Feb 2006 vol.50 N.2 p. 709-712


Satowa Suzuki,1 Tsutomu Yamazaki,2 Mitsuo Narita,3 Norio Okazaki,4 Isao Suzuki,5 Tomoaki Andoh,5 Mayumi Matsuoka,1 Tsuyoshi Kenri,1 Yoshichika Arakawa,1 and Tsuguo Sasaki1*

Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo,1 Department of Pediatrics, Saitama Medical School, Saitama,2 Sapporo Tetsudo Hospital, Hokkaido,3 Kanagawa Prefectural Institute of Public Health, Kanagawa,4 Department of Pediatrics, Chigasaki Municipal Hospital, Kanagawa, Japan5

Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumoniae infection (MR patients) treated with macrolides were compared with those of 26 patients with macrolide-susceptible M. pneumoniae infection (MS patients). The total febrile days and the number of febrile days during macrolide administration were longer in the MR patients than in the MS patients (median of 8 days versus median of 5 days [P = 0.019] and 3 days versus 1 day [P = 0.002], respectively). In addition, the MR patients were more likely than the MS patients to have had a change of the initially prescribed macrolide to another antimicrobial agent (63.6% versus 3.8%; odds ratio, 43.8; P * Corresponding author. Mailing address: Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, Tokyo 208-0011, Japan. Phone: (81) 425610771. Fax: (81) 425653315. E-mail:

Entry filed under: Antimicrobianos, Bacterias, Resistencia bacteriana.

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