Archive for March, 2008

Control mundial de la tuberculosis 2008

RESULTADOS PRINCIPALES

La carga mundial de la tuberculosis

Nota completa
http://www.who.int/tb/publications/global_report/2008/key_points/es/index.html

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March 29, 2008 at 12:48 pm Leave a comment

Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study

The Lancet  March 29 – April 4, 2008  V.371  N.9618  p.1108-1113

Articles

Anne von Gottberg, Keith P Klugman, Cheryl Cohen, Nicole Wolter, Linda de Gouveia, Mignon du Plessis, Ruth Mpembe, Vanessa Quan, Andrew Whitelaw, Rena Hoffmann, Nelesh Govender, Susan Meiring, Anthony M Smith, Stephanie Schrag, for the Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA)

abstract
http://www.thelancet.com/journals/lancet/article/PIIS0140673608603505/abstract

March 28, 2008 at 4:50 pm Leave a comment

Crystalluria from Acyclovir Use

N. Engl J Medicine  Mar 27, 2008  V.358  N.13  e14

Images in Clinical Medicine

FREE Full Text (CLIC en PDF)
http://content.nejm.org/cgi/content/full/358/13/e14?query=TOC

March 27, 2008 at 11:43 pm Leave a comment

C-Reactive Protein Is an Independent Predictor of Severity in Community-acquired Pneumonia

The American Journal of Medicine Mar 2008  V.121  N.3  p.219-225

Abstract
Background

C-reactive protein (CRP) is an acute phase protein synthesized by the liver primarily in response to interleukin-6. Initial studies have suggested that inflammatory markers may have a role in predicting severity. We investigated whether admission and day 4 CRP could predict severity in community-acquired pneumonia.

Methods
A prospective study was carried out over a 2-year period in a large teaching hospital. CRP was measured on admission and on day 4. The outcomes of interest were: 30-day mortality; need for mechanical ventilation and/or inotropic support; development of complicated pneumonia (lung abscess, empyema, or complicated parapneumonic effusion); the value of predictive tests were assessed using multivariate logistic regression.

Results
There were 570 patients included in the study; 30-day mortality was 9.6%. Low CRP levels showed a high negative predictive value for excluding 30-day mortality (CRP <10 mg/L=100%, CRP <50=99.1%, CRP <100=98.9%, CRP <200=94.9%). Low admission CRP levels <100 mg/L were independently associated with reduced 30-day mortality (odds ratio [OR] 0.18; 0.04-0.85), P=.03; need for mechanical ventilation and/or inotropic support (OR 0.21; 0.14-0.4), P=.002; and complicated pneumonia (OR 0.05; 0.01-0.35), P=.003.

A CRP that fails to fall by 50% or more within 4 days of admission is independently associated with increased 30 day mortality (OR 24.5; 6.4-93.4), P <.0001; need for mechanical ventilation and/or inotropic support (OR 7.1; 2.8-17.8), P <.0001 and complicated pneumonia (OR 15.4; 6.32-37.6), P <.0001.

Conclusions
Admission CRP <100 mg/L has reduced risk for 30-day mortality, need for mechanical ventilation and/or inotropic support, and complicated pneumonia. Failure of CRP to fall by 50% or more at day 4 leads to an increased risk for 30-day mortality, need for mechanical ventilation and/or inotropic support, and complicated pneumonia. C-reactive protein is an independent marker of severity in community-acquired pneumonia.

abstract
http://www.amjmed.com/article/S0002-9343(07)01180-1/fulltext

FREE Full Text (CLIC en  full text PDF) o directamente en el siguiente link:
http://download.journals.elsevierhealth.com/pdfs/journals/0002-9343/PIIS0002934307011801.pdf

March 27, 2008 at 6:45 pm Leave a comment

Infectious syphilis in high-income settings in the 21st century

The Lancet Infectious Diseases Mar 2008  V.8  p.244-253

Review

Kevin A Fenton MD  b ,   Romulus Breban PhD c,   Raffaele Vardavas PhD d,   Justin T Okano MS d,   Tara Martin e,   Sevgi Aral PhD a   and   Prof Sally Blower PhD d

abstract
http://www.thelancet.com/journals/laninf/article/PIIS1473309908700653/abstract

March 27, 2008 at 6:43 pm Leave a comment

Neuroinvasion by Mycoplasma pneumoniae in Acute Disseminated Encephalomyelitis

Emerging Infectious Diseases Journal  April 2008  V.14  N.4

Bernhard Stamm,*  Michael Moschopulos,* Hansjoerg Hungerbuehler,* Jeannette Guarner,† Gillian L. Genrich,† and Sherif R. Zaki†

*Kantonsspital Aarau, Aarau, Switzerland; and †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

FREE Full Text (CLIC en Download this article as PDF)
http://www.cdc.gov:80/eid/content/14/4/641.htm?s_cid=eid641_e

March 27, 2008 at 5:33 pm Leave a comment

Chagas Disease, France

Emerging Infectious Diseases Journal  April 2008  V.14  N.4

François-Xavier Lescure,*  Ana Canestri,† Hugues Melliez,‡ Stéphane Jauréguiberry,* Michel Develoux,* Richard Dorent,* Jean-Baptiste Guiard-Schmid,* Philippe Bonnard,* Faïza Ajana,‡ Valeria Rolla,§ Yves Carlier,¶ Frederick Gay,†Marie-Hélène Elghouzzi,# Martin Danis,† and Gilles Pialoux*

*Hôpital Tenon AP-HP, Paris, France; †Hôpital La Pitié Salpétrière AP-HP, Paris, France; ‡Le Centre Hospitalier de Tourcoing, Tourcoing, France; §Instituto de Pesquisa Clinica Evandro Chagas – Fiocruz, Rio de Janeiro, Brazil; ¶Université libre de Bruxelles, Brussels, Belgium; and #Etablissement Français du Sang d’lle de France, Paris, France

FREE Full Text (CLIC en Download this article as PDF)
http://www.cdc.gov:80/eid/content/14/4/644.htm?s_cid=eid644_e

March 27, 2008 at 2:04 am Leave a comment

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