Amikacin Monotherapy for Sepsis Caused by Panresistant Pseudomonas aeruginosa

April 21, 2011 at 5:02 pm Leave a comment

Antimicrobial Agents and Chemotherapy 1 Nov. 2010 V.54 N.11 P.4939-4941

Brice Layeux, Fabio Silvio Taccone, David Fagnoul, Jean-Louis Vincent, and Frederique Jacobs

Department of Infectious Diseases, Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium

Two patients with severe sepsis due to panresistant Pseudomonas aeruginosa, deteriorating despite therapy with colistin and β-lactams, were cured with a high daily dose (25 to 50 mg/kg) of amikacin to obtain a peak/MIC ratio of at least 8 to 10 (MIC = 16 µg/ml). Concomitant use of continuous venovenous hemodiafiltration (CVVHDF) provided no deterioration in renal function after treatment. High dosage of aminoglycosides combined with CVVHDF may represent a valuable therapeutic option for infection due to multiresistant pathogens.

abstract

http://aac.asm.org:80/cgi/content/abstract/54/11/4939?etoc

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Infecciones nosocomiales, Metodos diagnosticos, Resistencia bacteriana, Sepsis.

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