Lessons from Sickle Cell Disease in the Treatment and Control of Malaria

June 30, 2011 at 6:32 pm Leave a comment

N Engl J of Med June 30, 2011

Clinical Implications of Basic Research

Philip J. Rosenthal, M.D.

Malaria, especially infection with Plasmodium falciparum, has exerted strong selective pressure on the human genome. In a well-characterized, balanced polymorphism, persons who are homozygous for the sickle hemoglobin mutation (in which valine replaces glutamic acid at position6 inthe β-globin chain of hemoglobin A, producing hemoglobin S) have serious hematologic illness, but those who are heterozygous for the mutation (and have hemoglobin AS) are asymptomatic and relatively protected against severe falciparum malaria as compared with those who have normal hemoglobin.1 A recent study by Ferreira and colleagues2 offers an improved understanding of how hemoglobin AS protects against malaria, thereby providing insight into potential means of treating and controlling this disease…

abstract

http://www.nejm.org/doi/full/10.1056/NEJMcibr1105118

PDF

http://www.nejm.org/doi/pdf/10.1056/NEJMcibr1105118

 

Entry filed under: Antiparasitarios, Epidemiología, Infecciones emergentes, Infecciones parasitarias, Medicina del viajero.

Gram-negative prosthetic joint infection treated with debridement, prosthesis retention and antibiotic regimens including a fluoroquinolone Antitrypanosomal Therapy for Chronic Chagas’ Disease

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Trackback this post  |  Subscribe to the comments via RSS Feed


Calendar

June 2011
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
27282930  

Most Recent Posts


%d bloggers like this: