Archive for July 2, 2012

Management of HIV/HBV coinfection.

MedGenMed. 2006 Feb 7  V.8  N.1  P.:41.

Miller AO.

Division of Infectious Diseases and Immunology, New York University School of Medicine, New York, NY, USA.

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681933/?tool=pubmed

 

July 2, 2012 at 2:53 pm

Group B streptococcal infections in elderly adults.

Clin Infect Dis. 2005 Sep 15  V.41 N.6  P.839-47.

Edwards MS, Baker CJ.

Section of Infectious Disease, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA. morvene@bcm.tmc.edu

Abstract

Elderly adults account for >40% of persons with invasive group B streptococcal (GBS) disease and for >50% of GBS-associated deaths in theUnited States. The prevalence of colonization among healthy elderly adults (approximately 25%) is similar to that among women of childbearing age. Delineating contributions of comorbid conditions, altered integrity of anatomical barriers, and abnormalities in immune responses caused by immune senescence to pathogenesis require further investigation. Delayed clinical recognition of illness may contribute to poor outcome. Skin and soft-tissue infections and bacteremia with no identified focus are common manifestations of infection in elderly adults and younger nonpregnant adults. Urinary tract infection and pneumonia are presentations more often encountered in elderly persons than in younger adults. The safety and immunogenicity of GBS serotype V-tetanus toxoid conjugate vaccine in healthy elderly persons suggest the potential for vaccination as an approach to prevention of invasive GBS infections in elderly persons.

PDF

http://cid.oxfordjournals.org/content/41/6/839.full.pdf+html

July 2, 2012 at 2:51 pm

Understanding the regulation of Group B Streptococcal virulence factors.

Future Microbiol. 2009 Mar  V.4 N.2  P.201-21.

Rajagopal L.

Department of Pediatric Infectious Diseases, University of Washington & Seattle Children’s Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101-91304, USA. lakshmi.rajagopal@seattlechildrens.org

Abstract

Bacterial infections remain a significant threat to the health of newborns and adults. Group B Streptococci (GBS) are Gram-positive bacteria that are common asymptomatic colonizers of healthy adults. However, this opportunistic organism can also subvert suboptimal host defenses to cause severe invasive disease and tissue damage. The increasing emergence of antibiotic-resistant GBS raises more concerns for sustained measures in treatment of the disease. A number of factors that are important for virulence of GBS have been identified. This review summarizes the functions of some well-characterized virulence factors, with an emphasis on how GBS regulates their expression. Regulatory and signaling molecules are attractive drug targets in the treatment of bacterial infections. Consequently, understanding signaling responses of GBS is essential for elucidation of pathogenesis of GBS infection and for the identification of novel therapeutic agents

PDF

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691590/pdf/nihms114724.pdf

July 2, 2012 at 2:49 pm

Virologic Outcome of Using Tenofovir/Emtricitabine to Treat Hepatitis B in HIV-Coinfected Patients.

ISRN Gastroenterol. 2011  

Engell CA, Pham VP, Holzman RS, Aberg JA.

Department of Medicine, Division of Infectious Diseases and Immunology, New York University School of Medicine at Bellevue Hospital Center, New York, NY 10016, USA.

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168392/pdf/GASTROENTEROLOGY2011-405390.pdf

July 2, 2012 at 2:48 pm


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