Archive for February 20, 2013

In vitro activity of tedizolid (TR-700) against linezolid-resistant staphylococci.

J Antimicrob Chemother. 2012 Jan;67(1):167-9.

Rodríguez-Avial I, Culebras E, Betriu C, Morales G, Pena I, Picazo JJ.

Source

Servicio de Microbiología Clínica, Hospital Clínico San Carlos, Plaza Cristo Rey s/n, 28040 Madrid, Spain. irodriguezi.hcsc@salud.madrid.org

Abstract

OBJECTIVES:

To compare the activity of tedizolid (formally known as torezolid and TR-700) with that of 15 agents against a collection of linezolid-resistant staphylococci (164 coagulase-negative staphylococci and 5 Staphylococcus aureus).

METHODS:

Antimicrobial susceptibility tests were performed using the broth microdilution method following the recommendations of the CLSI.

RESULTS:

All isolates were susceptible to vancomycin and tigecycline. Based on the MIC(90) values, the potency of tedizolid against coagulase-negative staphylococci was >16-fold greater than that of linezolid. Tedizolid retained activity against most of the linezolid-resistant staphylococci tested, including multidrug-resistant isolates with elevated linezolid MICs (32 to >128 mg/L). Of the isolates, 79.2% and 31.4% were inhibited by tedizolid at ≤ 4 mg/L and ≤ 2 mg/L, respectively.

CONCLUSIONS:

The results of this study confirm the activity of tedizolid against linezolid-resistant staphylococci. This new oxazolidinone could have an important role as a potential therapeutic agent against multidrug-resistant staphylococci.

PDF

http://jac.oxfordjournals.org/content/67/1/167.full.pdf+html

February 20, 2013 at 8:59 pm

Perianal abscess: “Have I excluded leukaemia”?

Br Med J (Clin Res Ed). 1984 Dec 15;289(6459):1682.

Slater DN.

PDF

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1443796/pdf/bmjcred00532-0042.pdf

February 20, 2013 at 8:57 pm

Perianal tuberculosis: a case report and a review of the literature.

Case Rep Infect Dis. 2012;2012:852763.

Ibn Majdoub Hassani K, Ait Laalim S, Toughrai I, Mazaz K.

Source

Department of Surgery, University Hospital Hassan II, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Route de Sidi Hrazem, Fez 30000, Morocco.

Abstract

Extra pulmonary tuberculosis accounts for less than 15% of all cases of tuberculosis whereas the Intestinal one constitutes less than 1% of the extrapulmonary forms of the disease. The lesions of abdominal organs are more common while they rarely occur in the anoperineal area for the spread of the disease to the anus is extremely rare. We report a case of a 37-year-old male patient with large bilateral infected perianal tubercular ulcerations as well as pulmonary and peritoneal tuberculosis. The treatment was both surgical and medical and the therapy lasted for seven months. After six months from the beginning of the treatment, the lesion had totally disappeared and there is still no recurrence after one year of followup. Tuberculosis should generally be taken into consideration in the differential diagnosis of the ulcerative lesions of the anal and perianal regions for these lesions do occur in the said areas despite their rarity. The treatment is usually both surgical and medical so as to get excellent results.

PDF

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546444/pdf/CRIM.ID2012-852763.pdf

February 20, 2013 at 8:56 pm

Antibiotic prophylaxis and the risk of surgical site infections following total hip arthroplasty: timely administration is the most important factor.

Clin Infect Dis. 2007 Apr 1;44(7):921-7.

van Kasteren ME, Manniën J, Ott A, Kullberg BJ, de Boer AS, Gyssens IC.

Source

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands. M.v.Kasteren@elisabeth.nl

Abstract

BACKGROUND:

Surgical site infections (SSIs) following total hip arthroplasty can lead to prolonged hospitalization, increased morbidity and mortality, and high costs. This article analyzes the effect of various parameters of surgical antibiotic prophylaxis on the risk of SSI following total hip arthroplasty.

METHODS:

Data about SSI and potential prophylaxis-, patient-, and procedure-related risk factors were prospectively collected for 1922 patients who underwent elective total hip arthroplasty in 11 hospitals that participated in the Dutch intervention project, Surgical Prophylaxis and Surveillance. Multivariate logistic regression analysis was performed to correct for random variation among hospitals.

RESULTS:

SSIs (superficial and deep) occurred in 50 patients (2.6%). The highest odds ratios for SSI were found in patients who received prophylaxis after incision (2.8, 95% confidence interval [CI], 0.9-8.6; P=.07), had an American Society of Anesthesiology score that was >2 (2.8, 95% CI, 0.8-9.2; P=.09), and experienced a duration of surgery that was >75th percentile (2.5; 95% CI, 1.1-5.8; P=.04). Prolonged prophylaxis after the end of surgery and the use of antibiotic-impregnated cement did not contribute to fewer SSIs in this study.

CONCLUSIONS:

This study suggests that intervention programs in search of amendable factors to prevent SSI should focus on timely administration of antibiotic prophylaxis.

PDF

http://cid.oxfordjournals.org/content/44/7/921.full.pdf+html

Comment in

The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlProphylactic antibiotics: administration and timing before operation are more important than administration after operation. [Clin Infect Dis. 2007]

http://cid.oxfordjournals.org/content/44/7/928.full.pdf+html

 

 

February 20, 2013 at 8:54 pm


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