Update to CDC’s Sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infections.

February 28, 2013 at 2:39 pm

MMWR Morb Mortal Wkly Rep. 2012 Aug 10;61(31):590-4.

Centers for Disease Control and Prevention (CDC).

Abstract

Gonorrhea is a major cause of serious reproductive complications in women and can facilitate human immunodeficiency virus (HIV) transmission. Effective treatment is a cornerstone of U.S. gonorrhea control efforts, but treatment of gonorrhea has been complicated by the ability of Neisseria gonorrhoeae to develop antimicrobial resistance. This report, using data from CDC’s Gonococcal Isolate Surveillance Project (GISP), describes laboratory evidence of declining cefixime susceptibility among urethral N. gonorrhoeae isolates collected in the United States during 2006-2011 and updates CDC’s current recommendations for treatment of gonorrhea. Based on GISP data, CDC recommends combination therapy with ceftriaxone 250 mg intramuscularly and either azithromycin 1 g orally as a single dose or doxycycline 100 mg orally twice daily for 7 days as the most reliably effective treatment for uncomplicated gonorrhea. CDC no longer recommends cefixime at any dose as a first-line regimen for treatment of gonococcal infections. If cefixime is used as an alternative agent, then the patient should return in 1 week for a test-of-cure at the site of infection.

FULL TEXT

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6131a3.htm

PDF (see pag. 590)

http://www.cdc.gov/mmwr/pdf/wk/mm6131.pdf

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, CONSENSOS, GUIDELINES, HIV/SIDA, HIV/SIDA Infecciones Oportunistas, Infecciones de transmision sexual, Metodos diagnosticos, Resistencia bacteriana, Update.

Biomarkers in community-acquired pneumonia: A state-of-the-art review. Tackling multidrug-resistant gonorrhea: how should we prepare for the untreatable?


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