Archive for March 27, 2013

Bacterial pneumonia and pandemic influenza planning.

Emerg Infect Dis. 2008 Aug;14(8):1187-92.

Gupta RK, George R, Nguyen-Van-Tam JS.


Department of Infectious Diseases, John Radcliffe Hospital, Oxford, UK.


Pandemic influenza planning is well under way across the globe. Antiviral drugs and vaccines have dominated the therapeutic agenda. Far less work has been conducted on stockpiling and planning for deployment of antimicrobial drugs against secondary bacterial pneumonia, a cause of substantial illness and death in previous pandemics and epidemics. In the event of a pandemic, effective antimicrobial drug measures are expected to substantially benefit public health. We address issues regarding use of antimicrobial drugs as stocks of individual agents are diminished and the role of resistance surveillance in informing such policy. Furthermore, vaccination with polysaccharide and conjugate pneumococcal vaccines is considered as part of a pandemic strategy. Most illness and death from influenza are likely to occur in developing countries, where neuraminidase inhibitors and vaccines may be neither affordable nor available; thus, compared with industrialized countries, the benefits of treating bacterial complications in developing countries may be substantially greater.


March 27, 2013 at 2:24 pm

Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults

Emerging Infectious Diseases  April 2013 V.19  N.4 P.623-626

Philip J. Peters , John T. Brooks, Sigrid K. McAllister, Brandi Limbago, H. Ken Lowery, Gregory Fosheim, Jodie L. Guest, Rachel J. Gorwitz, Monique Bethea, Jeffrey Hageman, Rondeen Mindley, Linda K. McDougal, and David Rimland

Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.J. Peters, J.T. Brooks, S.K. McAllister, B. Limbago, G. Fosheim, R.J. Gorwitz, J. Hageman, L.K. McDougal); Veterans Affairs Medical Center, Atlanta (H.K. Lowery, J.L. Guest, M. Bethea, R. Mindley, D. Rimland); Emory University School of Medicine, Atlanta (D. Rimland)

Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007–2008, we enrolled HIV-infected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at enrollment and after 6 and 12 months. MRSA colonization was detected in 13%–15% of HIV-infected participants (n = 600, 98% male) at baseline, 6 months, and 12 months. MRSA colonization was detected in the nares only (41%), groin only (21%), and at both sites (38%). Over a median of 2.1 years of follow-up, 29 MRSA clinical infections occurred in 25 participants. In multivariate analysis, MRSA clinical infection was significantly associated with MRSA colonization of the groin (adjusted risk ratio 4.8) and a history of MRSA infection (adjusted risk ratio 3.1). MRSA prevention strategies that can effectively prevent or eliminate groin colonization are likely necessary to reduce clinical infections in this population.


March 27, 2013 at 2:20 pm


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