Risk of HIV transmission from patients on antiretroviral therapy: A position statement from the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy

January 29, 2015 at 8:40 am

Scandinavian Journal of Infectious Diseases OCT 2014 V.46 N.10

Jan Albert , Torsten Berglund , Magnus Gisslén , Peter Gröön , Anders Sönnerborg , Anders Tegnell , Anders Alexandersson , Ingela Berggren , Anders Blaxhult , Maria Brytting , Christina Carlander , Johan Carlson , Leo Flamholc , Per Follin , Axana Haggar , Frida Hansdotter , Filip Josephson , Olle Karlström , Fredrik Liljeros , Lars Navér , Karin Pettersson , Veronica Svedhem Johansson , Bo Svennerholm , Petra Tunbäck , Katarina Widgren

From the 1Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm

2Department of Clinical Microbiology, Karolinska University Hospital, Stockholm

3The Swedish Reference Group for Antiviral Therapy, Solna

4The Public Health Agency of Sweden, Solna

5Department of Infectious Diseases, University of Gothenburg, Gothenburg

6Department of Communicable Diseases Control and Prevention, Stockholm County Council, Stockholm

7Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Stockholm

8Department of Infectious Diseases, Karolinska University Hospital, Stockholm

9National Board of Health and Welfare, Stockholm

10Venhälsan/Infektion, Södersjukhuset, Stockholm

11Clinic of Infectious Diseases, County Hospital of Västmanland, Västerås

12Department of Infectious Diseases, University of Lund, Skåne University Hospital, Malmö

13Department of Communicable Disease Control and Prevention, Region Västra Götaland, Gothenburg

14Swedish Medical Products Agency, Uppsala

15Department of Sociology, Stockholm University, Stockholm

16Department of Paediatrics, Karolinska University Hospital, Stockholm

17Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm

18Department of Obstetrics, Karolinska University Hospital, Huddinge, Stockholm

19Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm

20Department of Clinical Virology, Sahlgrenska Academy, University of Gothenburg, Gothenburg

21Department of Dermatovenereology, University of Gothenburg, Gothenburg, Sweden

Correspondence: J. Albert, Department of Clinical Microbiology L2:02, Karolinska University Hospital Solna, S-171 76 Stockholm, Sweden. Tel: + 46 8 5177 9471. E-mail: jan.albert@ki.se

The modern medical treatment of HIV with antiretroviral therapy (ART) has drastically reduced the morbidity and mortality in patients infected with this virus. ART has also been shown to reduce the transmission risk from individual patients as well as the spread of the infection at the population level. This position statement from the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy is based on a workshop organized in the fall of 2012. It summarizes the latest research and knowledge on the risk of HIV transmission from patients on ART, with a focus on the risk of sexual transmission. The risk of transmission via shared injection equipment among intravenous drug users is also examined, as is the risk of mother-to-child transmission. Based on current knowledge, the risk of transmission through vaginal or anal intercourse involving the use of a condom has been judged to be minimal, provided that the person infected with HIV fulfils the criteria for effective ART. This probably also applies to unprotected intercourse, provided that no other sexually transmitted infections are present, although it is not currently possible to fully support this conclusion with direct scientific evidence. ART is judged to markedly reduce the risk of blood-borne transmission between people who share injection equipment. Finally, the risk of transmission from mother to child is very low, provided that ART is started well in advance of delivery.

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http://informahealthcare.com/doi/pdfplus/10.3109/00365548.2014.926565

Entry filed under: Antirretrovirales, Biología Molecular, Epidemiología, HIV/SIDA, HIV/SIDA Complicaciones, HIV/SIDA HAART, HIV/SIDA Laboratorio, HIV/SIDA Prevencion. Tags: .

Nonfoodborne Vibrio infections: an important cause of morbidity and mortality in the United States, 1997-2006. Delayed HIV diagnosis common in Sweden, 2003–2010


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