Genetics and hepatitis C: It’s good to be ‘CC’

February 16, 2015 at 10:43 am

Cleveland Clinic Journal of Medicine FEB 2015, V.82 N.2 P.97-104.

JOSE MARI PARUNGAO, MD

Department of Gastroenterology, Providence Hospital and Medical Centers, Southfield, MI

IBRAHIM A. HANOUNEH, MD

Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

BINU JOHN, MD

Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

NAIM ALKHOURI, MD

Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic

NIZAR N. ZEIN, MD

Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic; Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

ADDRESS: Nizar N. Zein, MD, Department of Gastroenterology and Hepatology, A100, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: zeinn@ccf.org

KEY POINTS

-In IL28B, the rs12979860 location can be occupied by either cytosine (C) or thymine (T). The CC genotype   is more favorable than the CT or TT genotype.

– Testing for the IL28B polymorphism is currently available and allows for better outcomes through proper   selection of treatment, particularly with interferon-based treatment.

– Although newer therapies have shifted toward regimens that do not use interferon, the IL28B polymorphism remains clinically significant, especially in light of the potentially prohibitive costs of the newer regimens, and   for patients in whom these treatments are contraindicated.

FULL TEXT

http://www.ccjm.org/current-issue/issue-single-view/genetics-and-hepatitis-c-its-good-to-be-cc/0afbe8ada94cdbab08fd0663c76e460e.html

 

http://www.ccjm.org/current-issue/issue-single-view/genetics-and-hepatitis-c-its-good-to-be-cc/fba845d117279400e300c61d443c5fa5.html?tx_ttnews%5BsViewPointer%5D=1

PDF

http://www.ccjm.org/uploads/media/Parungao_HepatitisC.pdf

Entry filed under: Antivirales no HIV, Biología Molecular, Hepatitis C, Infecciones virales, Metodos diagnosticos, Update. Tags: .

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