A longitudinal assessment of antimicrobial susceptibility among important pathogens collected as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) in France between 2004 and 2012.

February 25, 2015 at 8:28 am

Antimicrob Resist Infect Control. 2014 Dec 1;3(1):36.

Cattoir V1, Dowzicky MJ2.

1CHU de Caen, Microbiologie & Centre National de Référence de la Résistance aux Antibiotiques (laboratoire associé Entérocoques et résistances particulières des bactéries à Gram positif), Caen, France ; CHU de Caen, Service de Microbiologie – Niveau 3, Avenue de la Côte de Nacre-CS30001, 14033 Caen, Cedex 9, France.

2Pfizer Inc, Collegeville, PA USA.

Abstract

BACKGROUND:

Clinically important Gram-positive and -negative isolates were collected from patients in France between 2004 and 2012 as a part of the Tigecycline Evaluation and Surveillance Trial.

METHODS:

MICs were determined using methodology described by the Clinical and Laboratory Standards Institute.

RESULTS:

In total, 17,135 isolates were contributed by 29 medical centres; respiratory (25.1%) and cardiovascular (20.3%) sources predominated. High susceptibility was observed among Enterococcus spp. and Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA]) to linezolid (100%), tigecycline (≥99.8%) and vancomycin (≥94.6%). The percentage of MRSA decreased from 34.3% in 2004 to 20.0% in 2009 before increasing to 34.7% in 2012. Vancomycin, linezolid, levofloxacin and carbapenems were highly active (≥99.6%) against Streptococcus pneumoniae; 3.2% were PRSP. Escherichia coli showed peak susceptibility to the carbapenems (≥99.9%), tigecycline (99.3%) and amikacin (97.9%); significant (p < 0.01) decreases in susceptibility were observed for ampicillin, cefepime and ceftriaxone between 2004 and 2012. ESBL production among E. coli increased from 3.0% (2004) to 14.9% (2012). High susceptibility was noted among Haemophilus influenzae to levofloxacin (100%), amoxicillin-clavulanate (99.2%), carbapenems (≥98.7%) and ceftriaxone (98.5%); β-lactamase production fluctuated with no notable trend between 18.1% (2007) and 27.7% (2011). Klebsiella spp. were highly susceptible to carbapenems (≥99.6%) and amikacin (≥96.4%); significant (p < 0.01) decreases in amoxicillin-clavulanate, cefepime, ceftriaxone, levofloxacin, piperacillin-tazobactam and tigecycline susceptibility were observed among K. pneumoniae between 2004 and 2012. Only imipenem was highly active (96.5% susceptible) against Acinetobacter baumannii. Imipenem and amikacin (87.7% and 87.1% susceptible) were the most active agents against P. aeruginosa; 10.2% of isolates were categorized as multidrug resistant.

CONCLUSIONS:

Carbapenems, linezolid, tigecycline and vancomycin conserved good in vitro activity against most pathogens (according to their spectrum of activity) in France between 2004 and 2012.

PDF

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322957/pdf/13756_2014_Article_601.pdf

 

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Epidemiología, Infecciones cardio-vasculares, Infecciones respiratorias, Metodos diagnosticos, Resistencia bacteriana, Sepsis. Tags: .

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