Surgical Site Infections in Orthopedic Surgery – The Effect of Mupirocin Nasal Ointment in a Double-Blind, Randomized, Placebo-Controlled Study

February 27, 2015 at 7:59 am

Clinical Infectious Diseases AUG.15, 2002 V.35 N.4 P.353-358

D Kalmeijer1, H Coertjens2, P. M van Nieuwland-Bollen2, D Bogaers-Hofman2, G. A. J de Baere3, A Stuurman1, A van Belkum4, and J. A. J. W Kluytmans2

1Departments of Pharmacy, Amphia Hospital, Breda

2Departments of Clinical Microbiology and Infection Prevention, Amphia Hospital, Breda

3Departments of Orthopedic Surgery, Amphia Hospital, Breda

4Departments of Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, The Netherlands

Reprints or correspondence: M. D. Kalmeijer, Dept. of Pharmacy, Academic Medical Center, University of Amsterdam, Postbus 22660, 1100 DD Amsterdam, The Netherlands (

The objective of this study was to determine whether use of mupirocin nasal ointment for perioperative eradication of Staphylococcus aureus nasal carriage is effective in preventing the development of surgical site infections (SSIs).

A randomized, double-blind, placebo-controlled design was used. Either mupirocin or placebo nasal ointment was applied twice daily to 614 assessable patients from the day of admission to the hospital until the day of surgery.

A total of 315 and 299 patients were randomized to receive mupirocin and placebo, respectively. Eradication of nasal carriage was significantly more effective in the mupirocin group (eradication rate, 83.5% versus 27.8%).

In the mupirocin group, the rate of endogenous S. aureus infections was 5 times lower than in the placebo group (0.3% and 1.7%, respectively; relative risk, 0.19; 95% confidence interval, 0.02–1.62).

Mupirocin nasal ointment did not reduce the SSI rate (by S. aureus) or the duration of hospital stay



Entry filed under: Antimicrobianos, Bacterias, Desinfection and Sterilization, Epidemiología, Health Care-Associated Infections, Infecciones nosocomiales, Infecciones osteo-articulares-musculares, Infecciones relacionadas a prótesis, Infecciones sitio quirurgico, Metodos diagnosticos, Profilaxis Antibiótica en Cirugía - PAC, REPORTS.

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