The fundamental role of endothelial cells in hantavirus pathogenesis.
Front Microbiol. 2014 Dec 22;5:727.
Hepojoki J1, Vaheri A1, Strandin T1.
1Department of Virology, Haartman Institute, University of Helsinki Helsinki, Finland.
Hantavirus, a genus of rodent- and insectivore-borne viruses in the family Bunyaviridae, is a group of emerging zoonotic pathogens. Hantaviruses cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome in man, often with severe consequences.
Vascular leakage is evident in severe hantavirus infections, and increased permeability contributes to the pathogenesis.
This review summarizes the current knowledge on hantavirus interactions with hematopoietic and endothelial cells, and their effects on the increased vascular permeability.