Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study

March 15, 2015 at 3:11 pm

European J of Clin Microb & Inf Dis MARCH 2015 V.34 N.3 P.609-617

  1. Mehl, S. Harthug, S. Lydersen, J. Paulsen, B. O. Åsvold, E. Solligård, J. K. Damås & T.-H. Edna
  2. Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Post Box 333, 7601, Levanger, Norway
  3. Unit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
  4. Department of Medicine, Haukeland University Hospital, Bergen, Norway
  5. Institute of Medicine, University of Bergen, Bergen, Norway
  6. Regional Centre for Child and Youth Mental Health and Child Welfare—Central Norway, Norwegian University of Science and Technology, Trondheim, Norway
  7. Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
  8. Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway
  9. Department of Endocrinology, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway
  10. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
  11. Clinic of Anesthesia and Intensive Care, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway
  12. Department of Infectious Diseases, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway
  13. Department of Surgery, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway

e-mail: A. Mehl arne.mehl@hnt.no  

             Harthug stig.harthug@helse-bergen.no  

             Lydersen stian.lydersen@ntnu.no  

In several studies on patients with bloodstream infection (BSI), prior use of statins has been associated with improved survival. Gram-positive and Gram-negative bacteria alert the innate immune system in different ways.

We, therefore, studied whether the relation between prior statin use and 90-day total mortality differed between Gram-positive and Gram-negative BSI.

We conducted a prospective observational cohort study of 1,408 adults with BSI admitted to Levanger Hospital between January 1, 2002, and December 31, 2011. Data on the use of statins and other medications at admission, comorbidities, functional status, treatment, and outcome were obtained from the patients’ hospital records.

The relation of statin use with 90-day mortality differed between Gram-negative and Gram-positive BSI (p-value for interaction 0.01).

Among patients with Gram-negative BSI, statin users had significantly lower 90-day total mortality [odds ratio (OR) 0.42, 95 % confidence interval (CI) 0.23–0.75, p=0.003].

The association remained essentially unchanged after adjusting for the effect of sex, age, functional status before the infection, and underlying diseases that were considered confounders (adjusted OR 0.38, 95 % CI 0.20–0.72, p=0.003).

A similar analysis of patients with Gram-positive BSI showed no association of statin use with mortality (adjusted OR 1.22, 95 % CI 0.69–2.17, p=0.49).

The present study suggests that prior statin use is associated with a lower 90-day total mortality in Gram-negative BSI, but not in Gram-positive BSI.

abstract

http://link.springer.com/article/10.1007/s10096-014-2269-6?wt_mc=alerts.TOCjournals

 

PDF

http://download.springer.com/static/pdf/992/art%253A10.1007%252Fs10096-014-2269-6.pdf?auth66=1426442555_59e8b7b0cd72e4f66f1989ab7d5adf0d&ext=.pdf

 

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Resistencia bacteriana, Sepsis, Update.

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