Adipocytes Armed against Staphylococcus aureus

April 2, 2015 at 10:17 am

N Engl J Med April 2, 2015 V.372 P.1368-1370

Lloyd S. Miller, M.D., Ph.D.

From the Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore.

Staphylococcus aureus is a harmless commensal microorganism in the skin and mucosa. However, S. aureus is also a deadly pathogen responsible for the vast majority of skin infections.

Moreover, it causes pneumonia, sepsis, organ abscesses, endocarditis, and osteomyelitis.

In Alexander Fleming’s laboratory, in 1928, the golden-colored colonies of this gram-positive bacterium grew throughout a petri dish, except on an edge contaminated by the mold Penicillium notatum.

This led to Fleming’s discovery of penicillin, the golden age of antibiotic agents, and then the dreaded consequence of antibiotic resistance…..

PDF

http://www.nejm.org/doi/pdf/10.1056/NEJMcibr1500271

Entry filed under: Antimicrobianos, Bacterias, Epidemiología, Infecciones cardio-vasculares, Infecciones en piel y tej blandos, Infecciones osteo-articulares-musculares, Infecciones respiratorias, Metodos diagnosticos, Resistencia bacteriana, Sepsis, Update. Tags: .

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