Archive for April 23, 2015

Periprosthetic joint infections: a clinical practice algorithm.

Joints. 2015 Feb 13;2(4):169-74.

Volpe L1, Indelli PF2, Latella L3, Poli P1, Yakupoglu J4, Marcucci M3.

1Articular Replacements Excellence Center (CESAT) – Fondazione Onlus “…In Cammino…”, Fucecchio, Italy.

2New Mexico Veterans Affairs Health Care System (NMVAHCS) and Adult Reconstruction University of New Mexico, Department of Orthopaedics and Rehabilitation, Albuquerque, New Mexico, USA.

3Articular Replacements Excellence Center (CESAT) – Fondazione Onlus “…In Cammino…”, Fucecchio, Italy ; Orthopedic Clinic, University of Florence School of Medicine, Italy.

4The Breyer Center for Overseas Studies, Stanford University in Florence, Italy.



periprosthetic joint infection (PJI) accounts for 25% of failed total knee arthroplasties (TKAs) and 15% of failed total hip arthroplasties (THAs).

The purpose of the present study was to design a multidisciplinary diagnostic algorithm to detect a PJI as cause of a painful TKA or THA.


from April 2010 to October 2012, 111 patients with suspected PJI were evaluated. The study group comprised 75 females and 36 males with an average age of 71 years (range, 48 to 94 years). Eighty-four patients had a painful THA, while 27 reported a painful TKA. The stepwise diagnostic algorithm, applied in all the patients, included: measurement of serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels; imaging studies, including standard radiological examination, standard technetium-99m-methylene diphosphonate (MDP) bone scan (if positive, confirmation by LeukoScan was obtained); and joint aspiration with analysis of synovial fluid.


following application of the stepwise diagnostic algorithm, 24 out of our 111 screened patients were classified as having a suspected PJI (21.7%). CRP and ESR levels were negative in 84 and positive in 17 cases; 93.7% of the patients had a positive technetium-labeled bone scan, and 23% a positive LeukoScan. Preoperative synovial fluid analysis was positive in 13.5%; analysis of synovial fluid obtained by preoperative aspiration showed a leucocyte count of > 3000 cells μ/l in 52% of the patients.


the present study showed that the diagnosis of PJI requires the application of a multimodal diagnostic protocol in order to avoid complications related to surgical revision of a misdiagnosed “silent” PJI.


Level IV, therapeutic case series.



April 23, 2015 at 3:26 pm

Zika virus infection, Philippines, 2012.

Emerg Infect Dis. 2015 Apr;21(4):722-4.


Alera MT, Hermann L, Tac-An IA, Klungthong C, Rutvisuttinunt W, Manasatienkij W, Villa D, Thaisomboonsuk B, Velasco JM, Chinnawirotpisan P, Lago CB, Roque VG Jr, Macareo LR, Srikiatkhachorn A, Fernandez S, Yoon IK.

Philippines-AFRIMS (Armed Forces Research Institute of Medical Sciences), Cebu City, Philippines (M.T. Alera, J.M. Velasco, C.B. Lago); University of Toronto, Toronto, Ontario, Canada (L. Hermann); AFRIMS, Bangkok, Thailand (L. Hermann, C. Klungthong, W. Rutvisuttinunt, W. Manasatienkij, B. Thaisomboonsuk, P. Chinnawirotpisan, L.R. Macareo, S. Fernandez, I.-K. Yoon); Cebu City Health Department, Cebu City (I.A. Tac-An, D. Villa); Department of Health, Manila, Philippines (V.G. Roque, Jr.); University of Massachusetts Medical School, Worcester, Massachusetts, USA (A. Srikiatkhachorn)

To the Editor: Zika virus (ZIKV), a mosquitoborne flavivirus, was first isolated from a rhesus monkey in Uganda in 1947. This positive-sense, single-stranded RNA virus (family Flaviviridae, genus Flavivirus) has a 10,794-nt genome and is most closely related to Spondweni virus. Phylogenetic analyses have revealed 2 major lineages: Asian and African ….


April 23, 2015 at 3:22 pm

Zika virus outside Africa.

Emerg Infect Dis. 2009 Sep;15(9):1347-50.

Hayes EB1.

1Barcelona Centre for International Health Research, Barcelona, Spain.


Zika virus (ZIKV) is a flavivirus related to yellow fever, dengue, West Nile, and Japanese encephalitis viruses.

In 2007 ZIKV caused an outbreak of relatively mild disease characterized by rash, arthralgia, and conjunctivitis on Yap Island in the southwestern Pacific Ocean.

This was the first time that ZIKV was detected outside of Africa and Asia. The history, transmission dynamics, virology, and clinical manifestations of ZIKV disease are discussed, along with the possibility for diagnostic confusion between ZIKV illness and dengue.

The emergence of ZIKV outside of its previously known geographic range should prompt awareness of the potential for ZIKV to spread to other Pacific islands and the Americas.


April 23, 2015 at 3:20 pm

Zika virus.

Emerg Infect Dis. 2014 Jun;20(6):1090.


Zika virus is a mosquito-borne positive-sense, single-stranded RNA virus in the family Flaviviridae, genus Flavivirus that causes a mild, acute febrile illness similar to dengue …


April 23, 2015 at 3:18 pm


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