Penicillin allergy – A practical guide for clinicians

May 9, 2015 at 8:43 pm

Cleveland Clinic Journal of Medicine May 2015 V.82 N.5 P.295-300.

ALEXEI GONZALEZ-ESTRADA, MD

Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic

CRISTINE RADOJICIC, MD

Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic

ADDRESS: Alexei Gonzalez-Estrada, MD, Department of Allergy and Clinical Immunology, Respiratory Institute, A90, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: gonzala5@ccf.org

ABSTRACT

Penicillin allergy is the most commonly reported drug allergy in the United States. However, after undergoing a complete evaluation by a board-certified allergist, including skin testing, 90% of patients labeled as “penicillin-allergic” are able to tolerate penicillin.

Clinical presentation is key in classifying reactions as either mediated by or not mediated by immunoglobulin E (IgE), and in determining which patients may benefit from penicillin skin testing, graded-dose challenge, or desensitization.

Cross-reactivity between penicillin and other beta-lactams is less common than previously thought.

FULL TEXT

http://www.ccjm.org/current-issue/issue-single-view/penicillin-allergy-a-practical-guide-for-clinicians/a2a3023e2bee9ab01b1588d59cd57fe5.html

PDF

http://www.ccjm.org/uploads/media/Gonzalez-Estrada_PenicillinAllergy.pdf

Entry filed under: Antimicrobianos. Tags: .

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