Ceftaroline, a new broad-spectrum cephalosporin in the era of multiresistance.

May 25, 2015 at 2:36 pm

Enferm Infecc Microbiol Clin. 2014 Mar;32 Suppl 2:1-7.

Horcajada JP1, Cantón R2.

1Servicio de Enfermedades Infecciosas, Hospital Universitario del Mar, Institut Hospital del Mar d’Investigació Mèdica (IMIM), Barcelona, España.

2Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, España. Electronic address: rafael.canton@salud.madrid.org

Abstract

Antimicrobial resistance has increased during the last few years, representing a public health concern.

Among Gram-positive organisms, methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae are paradigms of resistance and of the dispersion of multiresistant clones.

Ceftaroline, a broad-spectrum cephalosporin that includes MRSA and penicillin-resistant S. pneumoniae, is the first β-lactam antibiotic useful in infections due to MRSA.

Phase-III clinical trials have demonstrated its efficacy in the treatment of community-acquired pneumonia and in skin and soft tissue infections, which are the current indications for ceftaroline.

Due to its microbiological and pharmacological (PK/PD) profiles, these indications could be expanded to include bacteremia, endocarditis, and even osteoarticular infections.

Another notable feature is the activity of this drug against Gram-negative bacilli susceptible to third generation cephalosporins, indicating that ceftaroline could be useful when these organisms are suspected or demonstrated in polymicrobial infections.

Clinical follow-up of ceftaroline use will more clearly define future ceftaroline indications.

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Infecciones cardio-vasculares, Infecciones en piel y tej blandos, Infecciones osteo-articulares-musculares, Infecciones respiratorias, Metodos diagnosticos, Resistencia bacteriana, Update. Tags: .

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