Archive for June, 2015

Diagnóstico microbiológico de las infecciones asociadas a dispositivos biomédicos EIMC 46 pags

Enf Infecc & Microbiol. Clínica FEB 2015

PDF

http://www.seimc.org/contenidos/documentoscientificos/procedimientosmicrobiologia/seimc-procedimientomicrobiologia52.pdf

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June 27, 2015 at 11:34 am

Epstein-barr virus-related hemophagocytic lymphohistiocytosis: hematologic emergency in the critical care setting.

Case Rep Hematol. 2015;2015:491567.

Hashemi-Sadraei N1, Vejpongsa P1, Baljevic M2, Chen L3, Idowu M1.

1Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

2Division of Cancer Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

3Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potential life-threatening clinical syndrome that results from uncontrolled activation of the immune system.

Secondary HLH, more commonly observed in adult patients, is seen in the context of underlying triggering conditions. Epstein-Barr virus (EBV) has been recognized as the leading infectious cause and is associated with a poor outcome.

As clinical and laboratory features of HLH could overlap with septic shock syndrome in most patients, the diagnosis of HLH, especially in adults, is the most challenging aspect of the disease that results in delayed recognition and treatment of rapidly progressive multiorgan system failure.

We report a case of Hemophagocytic lymphohistiocytosis in a patient who presented with signs of septic shock syndrome and we review the literature on the topic

PDF

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338404/pdf/CRIHEM2015-491567.pdf

June 27, 2015 at 11:32 am

Epstein-Barr Virus-Associated Lymphomas.

Semin Oncol. 2015 Apr;42(2):291-303.

Grywalska E1, Rolinski J2.

1Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Poland.

2Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Poland. Electronic address: ewelina.grywalska@gmail.com

Abstract

The Epstein-Barr virus (EBV) is the first identified human virus with a proven association with the pathogenesis of cancer. To maintain the integrity of the viral genome and to “get out” of the control of the host immune system, in the phase of the latent infection EBV shows the expression of several genes, including genes for six nuclear antigens, three latent membrane proteins, two short non-coding RNAs, and BamHI-A rightward transcripts.

The different patterns of expression of these latent genes determine the occurrence of different types of latency in the pathogenesis of particular malignancies. One of the most important features of EBV is its ability to infect various cell types and the consequent variety of diseases.

It has been shown that in humans, EBV infection may lead to the development of cancers, including those derived from hematopoietic cells.

Although cases of T-cell and epithelial cell infections have been documented, EBV is characterized mainly by tropism for B lymphocytes, and under certain conditions their infection may result in transformation to B-cell lymphoma.

This article discusses the mechanisms leading to the development of EBV-dependent lymphomas, and briefly characterizes these diseases.

PDF

http://www.seminoncol.org/article/S0093-7754(14)00301-7/pdf

June 27, 2015 at 11:30 am

World Health Organization Guidelines on Postexposure Prophylaxis for HIV: Recommendations for a Public Health Approach

Clin Infect Dis June 1, 2015 V.60 Suppl 3

PDF

http://cid.oxfordjournals.org/content/60/suppl_3/S161.full.pdf+html

June 27, 2015 at 11:28 am

The Strategic Use of Antiretrovirals to Prevent HIV Infection: A Converging Agenda

Clin Infect Dis June 1, 2015 V.60 Suppl 3

PDF

http://cid.oxfordjournals.org/content/60/suppl_3/S159.full.pdf+html

June 27, 2015 at 11:26 am

Human infections with Borrelia miyamotoi, Japan.

Emerg Infect Dis. 2014 Aug;20(8):1391-3.

Sato K, Takano A, Konnai S, Nakao M, Ito T, Koyama K, Kaneko M, Ohnishi M, Kawabata H.

Abstract

We confirmed infection of 2 patients with Borrelia miyamotoi in Japan by retrospective surveillance of Lyme disease patients and detection of B. miyamotoi DNA in serum samples.

One patient also showed seroconversion for antibody against recombinant glycerophosphodiester phosphodiesterase of B. miyamotoi.

Indigenous relapsing fever should be considered a health concern in Japan.

PDF

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111186/pdf/13-1761.pdf

June 21, 2015 at 7:50 pm

Prevalence of Borrelia miyamotoi in Ixodes ticks in Europe and the United States.

Emerg Infect Dis. 2014 Oct;20(10):1678-82.

Crowder CD, Carolan HE, Rounds MA, Honig V, Mothes B, Haag H, Nolte O, Luft BJ, Grubhoffer L, Ecker DJ, Schutzer SE, Eshoo MW.

Abstract

Borrelia miyamotoi, a relapsing fever-related spirochete transmitted by Ixodes ticks, has been recently shown to be a human pathogen.

To characterize the prevalence of this organism in questing Ixodes ticks, we tested 2,754 ticks for a variety of tickborne pathogens by PCR and electrospray-ionization mass spectrometry.

Ticks were collected from California, New York, Connecticut, Pennsylvania, and Indiana in the United States and from Germany and the Czech Republic in Europe from 2008 through 2012. In addition, an isolate from Japan was characterized. We found 3 distinct genotypes, 1 for North America, 1 for Europe, and 1 for Japan.

We found B. miyamotoi infection in ticks in 16 of the 26 sites surveyed, with infection prevalence as high as 15.4%.

These results show the widespread distribution of the pathogen, indicating an exposure risk to humans in areas where Ixodes ticks reside.

PDF

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193165/pdf/13-1583Final.pdf

June 21, 2015 at 7:49 pm

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