Central venous catheter-related bacteremia due to Tsukamurella species in the immunocompromised host: a case series and review of the literature.

June 19, 2015 at 2:55 pm

Clin Infect Dis. 2002 Oct 1;35(7):e72-7.

Schwartz MA1, Tabet SR, Collier AC, Wallis CK, Carlson LC, Nguyen TT, Kattar MM, Coyle MB.

1Department of Medicine, Division of Infectious Diseases, University of Washington, Seattle, WA, USA. margot.schwartz@vmmc.org

Abstract

We report 6 cases of bacteremia due to Tsukamurella species, all of which were in immunosuppressed patients with indwelling central venous catheters (CVCs).

Fewer than 20 cases of serious illness due to these gram-positive bacilli have been reported in the medical literature; these cases have mostly been ascribed to the species Tsukamurella paurometabola.

Tsukamurella species are frequently misidentified as Rhodococcus or Corynebacterium species. We used high-performance liquid chromatography to identify these organisms to the genus level and 16S ribosomal RNA gene sequencing and DNA-DNA dot blots for species identification.

Three of our isolates were identified as Tsukamurella pulmonis, 1 was identified as Tsukamurella tyrosinosolvans, and 1 was identified as a unique species. One isolate was not maintained long enough for species identification.

All patients were successfully treated with antimicrobial therapy and CVC removal. Infection with this organism should be considered in the immunosuppressed patient with an indwelling CVC and gram-positive bacilli in the blood.

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http://cid.oxfordjournals.org/content/35/7/e72.full.pdf+html

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Desinfection and Sterilization, Epidemiología, F.O.D, Health Care-Associated Infections, HIC no SIDA, Infecciones asociadas a catater IV, Infecciones nosocomiales, Metodos diagnosticos, REPORTS, REVIEWS, Sepsis. Tags: .

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