KPC and NDM-1 Genes in Related Enterobacteriaceae Strains and Plasmids from Pakistan and the United States
Emerging Infectious Diseases Jun 2015 V.21 N.6
Mitchell W. Pesesky1, Tahir Hussain1, Meghan Wallace, Bin Wang, Saadia Andleeb, Carey-Ann D. Burnham, and Gautam Dantas
Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA (M.W. Pesesky, T. Hussain. M. Wallace, B. Wang, C.D. Burnham, G. Dantas); National University of Sciences and Technology, Islamabad, Pakistan (T. Hussain, S. Andleeb)
To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase.
High similarities of the results indicate rapid spread of carbapenem resistance between strains, including globally disseminated pathogens.