The Control of Methicillin-Resistant Staphylococcus aureus Blood Stream Infections in England.

September 29, 2015 at 1:53 pm

Open Forum Infect Dis. 2015 Mar 12;2(2):ofv035.

Duerden B1, Fry C2, Johnson AP3, Wilcox MH4.

Author information

1Cardiff University Medical School , Heath Park , United Kingdom.

2Department of Health, Richmond House, London , United Kingdom.

3Department of Healthcare-Associated Infections and Antimicrobial Resistance , Centre for Infectious Disease Surveillance and Control , Public Health England , London , United Kingdom.

4Leeds Teaching Hospitals, University of Leeds and Public Health England , United Kingdom.


Methicillin-resistant Staphylococcus aureus (MRSA) blood stream infection (BSI) is a major healthcare burden in some but not all healthcare settings, and it is associated with 10%-20% mortality.

The introduction of mandatory reporting in England of MRSA BSI in 2001 was followed in 2004 by the setting of target reductions for all National Health Service hospitals.

The original national target of a 50% reduction in MRSA BSI was considered by many experts to be unattainable, and yet this goal has been far exceeded (∼80% reduction with rates still declining).

The transformation from endemic to sporadic MRSA BSI involved the implementation of serial national infection prevention directives, and the deployment of expert improvement teams in organizations failed to meet their improvement trajectory targets.

We describe and appraise the components of the major public health infection prevention campaign that yielded major reductions in MRSA infection.

There are important lessons and opportunities for other healthcare systems where MRSA infection remains endemic.


Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Epidemiología, Metodos diagnosticos, Resistencia bacteriana, REVIEWS, Sepsis, Update.

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