Archive for October 5, 2015

Cross border comparison of MRSA bacteraemia between The Netherlands and North Rhine-Westphalia (Germany): a cross-sectional study.

PLoS One. 2012;7(8):e42787.

van Cleef BA1, Kluytmans JA, van Benthem BH, Haenen A, Monen J, Daniels-Haardt I, Jurke A, Friedrich AW.

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1Centre for Infectious Disease Control Netherlands, RIVM National Institute for Public Health and The Environment, Bilthoven, The Netherlands.



We describe the impact of methicillin-resistant Staphylococcus aureus (MRSA) in two neighbouring regions in Europe with a comparable population size, North Rhine-Westphalia (NRW) in Germany and the Netherlands.


We compared the occurrence of MRSA in blood cultures from surveillance systems. In the Netherlands in 2009, 14 of 1,510 (0.9%) Staphylococcus aureus bacteraemia episodes under surveillance were MRSA. Extrapolation using the number of clinical admissions results in a total of 29 MRSA bacteraemia episodes in the Netherlands or 1.8 episodes per 1,000,000 inhabitants. In 2010 in NRW, 1,029 MRSA bacteraemias were reported, resulting in 57.6 episodes of MRSA bacteraemia per 1,000,000 inhabitants: a 32-fold higher incidence than in the Netherlands.


Based on an estimated attributable mortality of 15%, the Dutch approach would save approximately 150 lives per year by the prevention of bacteraemia only.



October 5, 2015 at 2:55 pm

Successful Treatment of Carbapenemase-Producing Pandrug-Resistant Klebsiella pneumoniae Bacteremia.

Antimicrob Agents Chemother. 2015 Oct;59(10):5903-8.

Camargo JF1, Simkins J2, Beduschi T3, Tekin A3, Aragon L4, Pérez-Cardona A5, Prado CE6, Morris MI2, Abbo LM2, Cantón R7.

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1Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA

2Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.

3Miami Transplant Institute and Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

4Department of Pharmacy, Jackson Memorial Hospital, Miami, Florida, USA.

5Department of Microbiology, Jackson Memorial Hospital, Miami, Florida, USA.

6Department of Microbiology, University of Miami, Miami, Florida, USA.

7Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain


New antibiotic options are urgently needed for the treatment of carbapenem-resistant Enterobacteriaceae infections.

We report a 64-year-old female with prolonged hospitalization following an intestinal transplant who developed refractory bacteremia due to a serine carbapenemase-producing pandrug-resistant isolate of Klebsiella pneumoniae.

After failing multiple antimicrobial regimens, the patient was successfully treated.


October 5, 2015 at 2:52 pm


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