Fulminant meningococcal septicemia: dissociation between plasma thrombopoietin levels and platelet counts.

October 8, 2015 at 3:56 pm

Clin Infect Dis. 2000 Apr;30(4):643-7.

Bjerre A1, Ovstebø R, Kierulf P, Halvorsen S, Brandtzaeg P.

Author information

1Department of Pediatrics and the Research and Development Group, Ullevål University Hospital, Oslo, Norway. a.k.bjerre@ioks.uio.no

Abstract

Thrombopoietin (TPO), interleukin (IL)-6, and platelets were measured serially in 9 patients with fulminant meningococcal septicemia and consumption coagulopathy. The results were compared with those of patients with meningococcal meningitis and mild meningococcemia (n=10) and with those of healthy control subjects (n=19). TPO levels in control subjects were below the detection limit (<63 pg/mL). In patients with fulminant meningococcal septicemia, the median TPO level on admission was 193 pg/mL (range, 133-401 pg/mL), and the level peaked within 3-7 days (median, 488 pg/mL; range, 239-1334 pg/mL). Platelet counts remained low, despite the elevated TPO levels. In patients with meningitis or meningococcemia, the median TPO level on admission was 112 pg/mL (range, <63-695 pg/mL), and the TPO level was not detectable within 48 h. Platelet counts for these patients remained within normal limits. Maximum IL-6 levels in patients with septicemia were observed on admission (median, 5317 pg/mL; range, 188-651,000 pg/mL) and increased earlier than TPO levels. In patients with fulminant septicemia, TPO level increases significantly whereas the level of circulating platelets does not.

PDF

http://cid.oxfordjournals.org/content/30/4/643.full.pdf

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Epidemiología, F.O.D, FIEBRE y RASH, Inmunizaciones, Metodos diagnosticos, REPORTS, Sepsis. Tags: .

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