Archive for November 21, 2015

Methicillin-Sensitive Staphylococcus aureus CC398 in Intensive Care Unit, France

Emerging Infectious Diseases SEPT 2014 V.20 N.9

Anne-Sophie Brunel, Anne-Laure Bañuls, Hélène Marchandin, Nicolas Bouzinbi, David Morquin, Estelle Jumas-Bilak, and Philippe Corne

Author affiliations: Institut de Recherche pour le Développement, Montpellier, France (A.-S. Brunel, A.-L. Bañuls, N. Bouzinbi, D. Morquin, P. Corne); Centre Hospitalier Universitaire de Montpellier, Montpellier (A.-S. Brunel, H. Marchandin, E. Jumas-Bilak, D. Morquin, P. Corne); Université Montpellier 1, Montpellier (H. Marchandin, E. Jumas-Bilak)

During testing for Staphylococcus aureus in an intensive care unit in France in 2011, we found that methicillin-sensitive S. aureus clonal complex 398 was the most frequent clone (29/125, 23.2%).

It was isolated from patients (5/89, 5.6%), health care workers (2/63, 3.2%), and environmental sites (15/864, 1.7%). Results indicate emergence of this clone in a hospital setting.

PDF

http://wwwnc.cdc.gov/eid/article/20/9/pdfs/13-0225.pdf

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November 21, 2015 at 7:51 pm

Coronavirus and Other Respiratory Illnesses Comparing Older with Young Adults.

Am J Med. 2015 Nov;128(11):1251.e11-20.

Gorse GJ1, Donovan MM2, Patel GB2, Balasubramanian S3, Lusk RH4.

Author information

1Section of Infectious Diseases, VA St Louis Health Care System, and Division of Infectious Diseases, Allergy & Immunology, Saint Louis University School of Medicine, St Louis, Mo. Electronic address: gorsegj@slu.edu

2Research Service, VA St Louis Health Care System, and Division of Infectious Diseases, Allergy & Immunology, Saint Louis University School of Medicine, St Louis, Mo.

3Research Service, VA St Louis Health Care System, and Washington University in St Louis, St Louis, Mo.

4Section of Infectious Diseases, VA St Louis Health Care System, and Division of Infectious Diseases, Allergy & Immunology, Saint Louis University School of Medicine, St Louis, Mo.

Abstract

BACKGROUND:

Study of human coronavirus and other virus-associated respiratory illnesses is needed to describe their clinical effects on chronically ill, older adults.

METHODS:

A prospective study during 2009 to 2013 clinically assessed acute respiratory illnesses soon after onset and 3 to 4 weeks later in patients aged ≥60 years with chronic lung and heart diseases (group 1, 100 subjects) and healthy adults aged 18 to 40 years (group 2, 101 subjects). Respiratory secretions were tested for nucleic acids of a panel of respiratory viruses. An increase in antibody titer was assessed for 4 coronavirus strains.

RESULTS:

Virus-associated illnesses (29 [39.1%] of 74 illnesses in group 1 and 59 [48.7%] of 121 illnesses in group 2) occurred in all calendar quarters, most commonly in the first and fourth quarters. Coronaviruses (group 1: 14 [18.9%] illnesses; group 2: 26 [21.5%] illnesses) and enteroviruses/rhinoviruses (group 1: 14 [18.9%] illnesses; group 2: 37 [30.6%] illnesses) were most common. Virus co-infections occurred in 10 illnesses. Illnesses with 9 to 11 symptoms were more common in group 1 (17 [23.0%]) than in group 2 (15 [12.4%]) (P < .05). Compared with group 2, more group 1 subjects reported dyspnea, more severe disease of longer duration, and treatment for acute illness with prednisone and antibiotics. Coronavirus-associated illnesses (percent of illnesses, group 1 vs group 2) were characterized by myalgias (21% vs 68%, P < .01), chills (50% vs 52%), dyspnea (71% vs 24%, P < .01), headache (64% vs 72%), malaise (64% vs 84%), cough (86% vs 68%), sputum production (86% vs 60%), sore throat (64% vs 80%), and nasal congestion (93% vs 96%).

CONCLUSIONS:

Respiratory illnesses were commonly associated with coronaviruses and enteroviruses/rhinoviruses affecting chronically ill, older patients more than healthy, young adults.

abstract

http://www.amjmed.com/article/S0002-9343(15)00518-5/abstract

 

PDF

http://www.amjmed.com/article/S0002-9343(15)00518-5/pdf

November 21, 2015 at 8:06 am


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