Treatment of Tuberculosis
N Engl J of Med NOV.26, 2015 V.373 P.2149-2160
C.R. Horsburgh, Jr., C.E. Barry III, and C. Lange
From the Departments of Epidemiology, Biostatistics, and Medicine and the Center for Global Health and Development, Boston University, Boston (C.R.H.); the Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, and the Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa (C.E.B.); and the Division of Clinical Infectious Diseases, German Center for Infection Research (DZIF) Tuberculosis Unit, Research Center Borstel, Borstel, and International Health/Infectious Diseases, University of Lübeck, Lübeck — both in Germany (C.L.). Address reprint requests to Dr. Horsburgh at the Department of Epidemiology, Boston University School of Public Health, 715 Albany St., T3E, Boston MA 02118, or at firstname.lastname@example.org
Tuberculosis, a scourge since prehistoric times, affects more than 9 million people and causes the death of 1.5 million people each year. Effective treatment has been available for 60 years, but such treatment takes at least 6 months, and resistance to the drugs, which is increasing throughout the world, threatens the effectiveness of treatment.1 This review summarizes the theoretical principles of tuberculosis treatment, current therapeutic approaches, areas of uncertainty, and persistent challenges ….