Case fatality ratio and mortality rate trends of community-onset Staphylococcus aureus bacteraemia.
Clin Microbiol Infect. 2014 Oct;20(10):O630-2.
Tom S1, Galbraith JC, Valiquette L, Jacobsson G, Collignon P, Schønheyder HC, Søgaard M, Kennedy KJ, Knudsen JD, Ostergaard C, Lyytikäinen O, Laupland KB; International Bacteraemia Surveillance Collaborative.
1University of Calgary, Calgary, AB, Canada.
Lethal outcomes can be expressed as a case fatality ratio (CFR) or as a mortality rate per 100 000 population per year (MR). Population surveillance for community-onset methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus bacteraemia was conducted in Canada, Australia, Sweden and Denmark to evaluate 30-day CFR and MR trends between 2000 and 2008. The CFR was 20.3% (MSSA 20.2%, MRSA 22.3%) and MR was 3.4 (MSSA 3.1, MRSA 0.3) per 100 000 per year. Although MSSA CFR was stable the MSSA MR increased; MRSA CFR decreased while its MR remained low during the study. Community-onset S. aureus bacteraemia, particularly MSSA, is associated with major disease burden. This study highlights complementary information provided by evaluating both CFR and MR.