CMV in the gut: a critical review of CMV detection in the immunocompetent host with colitis

January 28, 2016 at 2:33 pm

European J of Clinical Microb & Infec Dis January 2015 V.34 N.1 P.13-18

  1. L. Goodman , C. D. Murray, J. Watkins, P. D. Griffiths, D. P. Webster
  2. Department of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK
  3. Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, NW3 2QG, UK
  4. Department of Cellular Pathology, Royal Free London NHS Foundation Trust, London, NW3 2QG, UK
  5. Centre for Virology, University College London Medical School, Rowland Hill Street, London, NW3 2PF, UK

Abstract

As scientific techniques for the detection of cytomegalovirus (CMV) improve, we are able to detect small amounts of CMV in the mucosal wall. As clinicians, we are unsure how to interpret the results of this novel test. There is controversy in the literature as to the significance of the detection of CMV in the gut. Whilst the importance of CMV and reactivation of the virus is clear in those patients such as allograft recipients with established immune compromise, the role is less clear in patients with less damaged immune systems. We explore whether the detection of CMV in such cases influences outcome and how it should be optimally managed. We discuss the optimal management of such cases, according to current guidelines, with a review of the literature.

abstract

http://link.springer.com/article/10.1007/s10096-014-2212-x

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Entry filed under: Antivirales no HIV, Biología Molecular, Infecciones gastrointestinales, Infecciones virales, Metodos diagnosticos, REVIEWS, Sepsis, Update. Tags: .

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