Archive for January 29, 2016

Brote de Encefalitis de San Luis en el área metropolitana Buenos Aires

Medicina Junio 2011 V.71 N.3

Alfredo Seijo1, Alejandra Morales2, Gladys Poustis1, Yamila Romer1, Ernesto Efron3, Guillermo Vilora4, Susana Lloveras1, Sergio Giamperetti1, Teresita Puente5, Jessica Monroig1, Victoria Luppo2, Delia Enria2

1Hospital de Enfermedades Infecciosas Francisco J. Muñiz,

2Instituto Nacional de Enfermedades Virales Humanas, J. Maiztegui, Pergamino,

3Hospital Británico,

4Hospital Ramos Mejía,

5Sanatorio Julio Méndez, Buenos Aires

Resumen

Se describen los hallazgos epidemiológicos y clínicos de 13 enfermos con diagnóstico de infección por virus de la encefalitis de San Luis, con transmisión entre enero y marzo de 2010, en el Area Metropolitana Buenos Aires (AMBA).

Los 13 enfermos, promedio de edad 38 años, tuvieron un comienzo agudo caracterizado por hipertermia y cefalea.

Entre los días dos y diez de iniciados los síntomas, 7/13 enfermos tuvieron signos y síntomas de compromiso neurológico caracterizado por meningitis sin signos encefálicos en 1/7.

En 6/7 los hallazgos más frecuentes fueron: rigidez de nuca, desorientación temporoespacial, fotofobia, confusión y alteración del lenguaje.

Dos resonancias magnéticas y un electroencefalograma presentaron signos de afectación de lóbulos temporales.

El líquido cefalorraquídeo se caracterizó por pleocitosis con predominio de células mononucleadas, glucorraquia normal y discreto aumento de proteínas. No hubo casos fatales. En 6/13 pacientes la sospecha clínica inicial fue dengue.

Por la agrupación espacial y temporal de los casos puede considerarse un brote epidémico, el primero conocido en el AMBA, ya que no se había notificado previamente la circulación epidémica del virus.

PDF

http://www.scielo.org.ar/pdf/medba/v71n3/v71n3a03.pdf

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January 29, 2016 at 2:48 pm

Pneumococcal empyema and complicated pneumonias: global trends in incidence, prevalence, and serotype epidemiology

European J of Clinical Microb & Infec Dis June 2014 V.33 N.6 P.879-910

  1. A. Fletcher , H.-J., M. Syrochkina, G. Sylvester
  2. Pfizer, Inc., 23–25, avenue du Dr Lannelongue, 75668, Paris Cedex 14, France
  3. Pfizer, Inc., Yekaterinburg, Russia
  4. Pfizer Inc., Collegeville, PA, USA

Abstract

This review evaluates the serotype epidemiology of complicated pneumococcal pneumonia (CPP) during the period 1990–2012. PubMed and EMBASE were searched using the terms “empyema”, “complicated pneumonia”, “pleural infection”, “necrotizing pneumonia”, “pleural effusion”, “parapneumonic effusion”, “pneumatocele”, or “lung abscess”; “pneumococcal” or “Streptococcus pneumoniae”; and “serotype” for studies on the epidemiology of complicated pneumonias published from January 1, 1990 to October 1, 2013.

Studies with data on incidence and serotypes were included; reviews, case reports, and conference abstracts were excluded. Of 152 papers, 84 fitted the inclusion criteria.

A few pneumococcal serotypes were predominant causes of CPP, particularly serotypes 1, 19A, 3, 14, and 7F. CPP was a more common manifestation of pneumococcal disease among older (>2 years old) than younger children.

The data support increases in both reported incidence rates and proportions of CPP in children and adults during the period 1990–2012; specific increases varied by geographic region.

The proportions of serotype 3 and, particularly in Asia, serotype 19A CPP have increased, whereas most studies show declines in serotype 14. Serotype 1 has been a predominant cause of CPP since 1990, while antibiotic resistance was infrequent among serotype 1 isolates.

The reported incidence and proportions of CPP among pneumonia cases steadily increased from 1990 to 2012. Several factors might account for these increases, including enhanced disease detection due to a higher index of suspicion, more sophisticated diagnostic assays, and changes in the prevalence of serotypes with capacity to invade the pleural space that were not targeted by the 7-valent pneumococcal conjugate vaccine (PCV7).

abstract

http://link.springer.com/article/10.1007/s10096-014-2062-6

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January 29, 2016 at 7:54 am


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