Archive for February 13, 2016

Editor’s Choice: Antifungal therapy: drug–drug interactions at your fingertips

Journal of Antimicrobial Chemotherapy February 2016 V.71 N.2 P.285-289

Vincent J. Lempers and Roger J. Brüggemann

1Radboud University Medical Center, Department of Pharmacy, Nijmegen, The Netherlands

2Radboud Institute for Health Sciences, Nijmegen, The Netherlands

The Information Age has revolutionized the ability of healthcare professionals (HCPs) to oversee a substantial body of clinically relevant information literally at one’s fingertips.

In the field of clinical pharmacology, this may be particularly useful for managing drug–drug interactions (DDIs). A thorough understanding of the underlying mechanisms of DDIs allows the HCP to predict such interactions and avoid those of greatest clinical significance.

Specifically, successful treatment with antifungal agents is complicated by the high potential to interact with other concomitant medications.

We describe here the development of a real-time knowledge base of DDIs with antifungal agents, providing expert recommendations to HCPs on how to handle DDIs with these drugs.

This new resource will facilitate rapid identification, quantification and classification of these DDIs by clinicians with varying levels of experience and resources worldwide, ultimately improving patient safety and strengthening health systems.



February 13, 2016 at 8:32 pm

Antibiotics: from prehistory to the present day

Journal of Antimicrobial Chemotherapy March 2016 V.71 N.3 P.572-575

Kate Gould

Newcastle Public Health Laboratory, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK

Antimicrobials have been in use for many thousands of years in a variety of formats.

In this article, I trace how we have moved from ingenious use of agents available in the environment to chemically engineered agents….


February 13, 2016 at 8:29 pm

Zika Virus Infection in a Massachusetts Resident After Travel to Costa Rica: A Case Report

Annals of Internal Medicine FEBRUARY 10, 2016


Lin H. Chen, MD

Mount Auburn Hospital, Harvard Medical School, and GeoSentinel Surveillance Network, Cambridge, Massachusetts.

Zika, a mosquito-borne flavivirus, has rapidly spread through South and Central America and the Caribbean since being recognized in Brazil in 2015. Here, we describe a case in a U.S. resident after travel to Costa Rica….




February 13, 2016 at 5:14 pm

Manifestaciones neurológicas durante la infección por el virus del dengue

INFECTIO OCT 2014 V.18 N.4

Jaime Castellanos a, Jorge Bello a, Myriam Velandia-Romero,

Grupo de Virología, División de Investigaciones, Universidad El Bosque, Bogotá, Colombia

El dengue es la enfermedad viral transmitida por mosquitos más importante en el mundo. Alrededor del 10% de los pacientes con dengue, pueden presentar alteraciones neurológicas durante o después de la infección, asociadas a la replicación viral en el tejido, a la respuesta inmunológica local, a la disfunción endotelial y a signos hemorrágicos en el tejido.

En muchos de estos casos se ha detectado virus o anticuerpos en el tejido, sugiriendo la invasión del virus al encéfalo, sin embargo, no siempre es posible hacer esta relación, dando origen a una gran pregunta: ¿son los daños del tejido nervioso producto de una encefalopatía asociada a disfunción extraneural o son debidos a la infección misma del tejido?

Como sigue siendo controversial la interpretación de los signos neurológicos durante el dengue, a continuación presentamos algunas generalidades del virus, sus forma clínicas y algunas evidencias clínicas y experimentales que intentan explicar y asociar la neuroinfección y la neuropatogenia por DENV.



February 13, 2016 at 12:50 pm

Dengue y embarazo

Medicina Clínica ENERO 2009 V.132 N.1


Duly Torres-Cepeda a, Joel Santos-Bolívar a, Elvia Peña-Paredes a, Eduardo Reyna-Villasmil a

a Servicio de Obstetricia y Ginecología-Maternidad Dr. Nerio Belloso, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.

Sr. Editor

El dengue es una infección causada por Flavivirus, endémica de los trópicos y subtrópicos, que afecta a 100 millones de personas al año.

Se transmite por la picadura del mosquito Aedes1,2. La infección puede ser asintomática o presentarse como fiebre hemorrágica. Se conocen 4 serotipos distintos del virus causante de la enfermedad.

El período de incubación normal de la enfermedad es de 3 a 8 días3. El virus es detectable en humanos de 6 a 18 h antes de la aparición de los síntomas.

La infección por un serotipo confiere protección contra la reinfección del mismo serotipo, mientras que la infección por un serotipo diferente puede predisponer a graves complicaciones….



February 13, 2016 at 12:47 pm

Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses — Brazil, 2015

MMWR Morb Mortal Wkly Rep 2016;65(Early Release):1–2

Notes from the Field

Roosecelis Brasil Martines, MD, PhD; Julu Bhatnagar, PhD; M. Kelly Keating, DVM; et al.

A surge in the number of children born with microcephaly has been noted in regions of Brazil with a high prevalence of suspected Zika virus disease.

This report describes evidence of a link between Zika virus infection and microcephaly and fetal demise through detection of viral RNA and antigens in brain tissues from infants with microcephaly and placental tissues from early miscarriages.




February 13, 2016 at 12:45 pm

Local Transmission of Zika Virus — Puerto Rico, November 23, 2015–January 28, 2016

MMWR Morb Mortal Wkly Rep 2016;65(Early Release):1–6

Dana L. Thomas, MD; Tyler M. Sharp, PhD; Jomil Torres, MS; et al.

On December 31, 2015, the Puerto Rico Department of Health reported the first locally acquired case of Zika virus disease in a jurisdiction of the United States in a patient from southeastern Puerto Rico.

Zika virus is expected to continue to spread throughout the territory, and the 3.5 million residents of Puerto Rico, including approximately 43,000 pregnant women per year, are at risk for Zika virus infection.



February 13, 2016 at 12:43 pm


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