Azole Resistance in Aspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?
Clinical Infectious Diseases February 1, 2016 V.62 N.3 P.362-368
Paul E. Verweij, Anuradha Chowdhary, Willem J. G. Melchers, and Jacques F. Meis
1Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands
2Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, India
3Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
Azole resistance in Aspergillus fumigatus has now been reported from 6 continents and is emerging as a global health problem.
The epidemiology, spread of azole resistance, the clinical implications, and directions of research are highlighted.