Trends in nosocomial infections and multidrug-resistant microorganisms in Spanish pediatric intensive care units.

February 26, 2016 at 7:43 am

Enferm Infecc Microbiol Clin. 2015 Sep 10. pii: S0213-005X(15)00285-2.

Jordan Garcia I1, Esteban Torné E2, Bustinza Arriortua A3, de Carlos Vicente JC4, García Soler P5, Concha Torre JA6, Flores González JC7, Madurga Revilla P8, Palomar Martínez M9; VINCIP Study Group, from Spanish Society of Pediatric Intensive Care (SECIP).

Author information

1Unidad de Cuidados Intensivos Pediátricos, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain. Electronic address:

2Unidad de Cuidados Intensivos Pediátricos, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.

3Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

4Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Son Espases, Palma, Mallorca, Spain.

5Unidad de Cuidados Intensivos Pediátricos, Hospital Regional Universitario Carlos Haya de Málaga, Málaga, Spain.

6Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Central de Asturias, Oviedo, Spain.

7Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Puerta del Mar de Cádiz, Cádiz, Spain.

8Unidad de Cuidados Intensivos Pediátricos, Hospital Infantil Universitario Miguel Servet de Zaragoza, Zaragoza, Spain.

9Unidad de Medicina Intensiva, Hospital Universitario Arnau de Vilanova de Lleida, Spain.



Nosocomial infections (NI) are a major healthcare problem. National surveillance systems enable data to be compared and to implement new measures to improve our practice.


A multicentre, prospective, descriptive and observational study was conducted using the data from surveillance system for nosocomial infections created in 2007 for Spanish pediatric intensive care units. Data were collected for one month, between 01 and 31 March, for every study year (2008-2012). The objective was to report 5-years of NI surveillance data, as well as trends in infections by multidrug resistant organisms in Spanish pediatric intensive care units.


A total of 3667 patients were admitted to the units during the study period. There were 90 (2.45%) patients with nosocomial infections. The mean rates during the 5 years study were: central line-associated bloodstream infection, 3.8/1000 central venous catheter-days, Ventilator-associated pneumonia 7.5/1000 endotracheal tube-days, and catheter-associated urinary tract infections 4.1/1000 urinary catheter-days. The comparison between the 2008 and 2009 rates for nosocomial infections did not show statistically significant differences. All rates homogeneously decreased from 2009 to 2012: central line-associated bloodstream infection 5.83 (95% CI 2.67-11.07) to 0.49 (95% CI 0.0125-2.76), P=0.0029; ventilator-associated pneumonia 10.44 (95% CI 5.21-18.67) to 4.04 (95% CI 1.48-8.80), P=0.0525; and Catheter-associated urinary tract infections 7.10 (95% CI 3.067-13.999) to 2.56 (95% CI 0.697-6.553), P=0.0817; respectively. The microorganism analysis: 63 of the 99 isolated bacteria (63.6%) were Gram-negative bacteria (36.5% were resistant), 19 (19.2%) Gram-positive bacteria, and 17 (17.2%) were Candida spp. infections.


The local surveillance systems provide information for dealing with nosocomial infections rates.



Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Epidemiología, Health Care-Associated Infections, Infecciones asociadas a catater IV, Infecciones nosocomiales, Infecciones respiratorias, Infecciones urinarias, Metodos diagnosticos, Resistencia bacteriana, Sepsis.

Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America Catheter-associated urinary tract infections in intensive care units at a university hospital in Turkey.


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