We Are Seeing More Sepsis…. But Are We Seeing the Whole Picture?
Clinical Infectious Diseases March. 15, 2016 V.62 N.6 P.704-706
Valerie C. Cluzet and Ebbing Lautenbach
1Division of Infectious Diseases, Department of Medicine
2Center for Clinical Epidemiology and Biostatistics
3Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia
Correspondence: E. Lautenbach, University of Pennsylvania, 502A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 (email@example.com).
In determining how to most effectively allocate limited resources, it is imperative to accurately define the burden of a given disease. As the number of data sources available for epidemiologic analyses continues to increase, clearly elucidating the relative strengths and weaknesses of these potentially valuable resources is imperative. Evaluating emerging trends in the incidence of specific conditions is vital in most efficiently directing efforts to preventive or therapeutic initiatives. These efforts must, however, be based on the careful examination of the source data as well as the potential impact of external forces.
In this context, it is useful to consider the recent work focused on sepsis. Sepsis is the most costly condition in the United States, and costs continue to increase at a rate much higher than for overall hospital stays [1, 2]. Several studies have reported a recent rise in the incidence of sepsis [3, 4]. This work contributed to the development of large-scale campaigns, most notably the Surviving Sepsis Campaign, to improve the diagnosis and treatment of sepsis . Although overall mortality related to sepsis has been increasing due to the general increased incidence of sepsis, the case-fatality rate has been decreasing over a similar period of time. This has been thought to be, in part, an effect of such campaigns. More work is needed to clearly define trends in sepsis incidence and outcomes to evaluate the effectiveness of such interventions.
In this light, the work by Gohil and colleagues in this issue of Clinical Infectious Diseases represents an important advance in the …