Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant

April 2, 2016 at 9:25 am

Journal of Clinical Microbiology October 2015 V.53 N.10 P.3341-3344

Tommaso Giani, Fabio Arena, Guendalina Vaggelli, Viola Conte, Adriana Chiarelli, Lucia Henrici De Angelis, Rossella Fornaini, Maddalena Grazzini, Fabrizio Niccolini, Patrizia Pecile, and Gian Maria Rossolini

aDepartment of Medical Biotechnologies, University of Siena, Siena, Italy

bClinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy

cHospital Pharmacy Unit, Florence Careggi University Hospital, Florence, Italy

dHospital Medical Direction, Florence Careggi University Hospital, Florence, Italy

eDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy

fDon Carlo Gnocchi Foundation, Florence, Italy

We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption.

The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3.

PDF

http://jcm.asm.org/content/53/10/3341.full.pdf

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Epidemiología, Health Care-Associated Infections, Infecciones nosocomiales, Metodos diagnosticos, Resistencia bacteriana, Sepsis, Update. Tags: .

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