Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant
Journal of Clinical Microbiology October 2015 V.53 N.10 P.3341-3344
Tommaso Giani, Fabio Arena, Guendalina Vaggelli, Viola Conte, Adriana Chiarelli, Lucia Henrici De Angelis, Rossella Fornaini, Maddalena Grazzini, Fabrizio Niccolini, Patrizia Pecile, and Gian Maria Rossolini
aDepartment of Medical Biotechnologies, University of Siena, Siena, Italy
bClinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy
cHospital Pharmacy Unit, Florence Careggi University Hospital, Florence, Italy
dHospital Medical Direction, Florence Careggi University Hospital, Florence, Italy
eDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy
fDon Carlo Gnocchi Foundation, Florence, Italy
We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption.
The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3.