Results from the Survey of Antibiotic Resistance (SOAR) 2012–14 in Thailand, India, South Korea and Singapore

April 5, 2016 at 7:52 pm

Journal of Antimicrobial Chemotherapy May 2016 V.71 Suppl 1 i3-i19

Torumkuney, R. Chaiwarith, W. Reechaipichitkul, K. Malatham, V. Chareonphaibul, C. Rodrigues, D. S. Chitins, M. Dias, S. Anandan, S. Kanakapura, Y. J. Park, K. Lee, H. Lee, J. Y. Kim, Y. Lee, H. K. Lee, J. H. Kim, T. Y. Tan, Y. X. Heng, P. Mukherjee, and I. Morrissey

1GlaxoSmithKline, 980 Great West Road, Brentford, Middlesex TW8 9GS, UK

2Faculty of Medicine, Chiang Mai University, Maharaj Nakorn Chiang Mai Hospital, 110 Intavaroros Road, Tambon Sribhoom, Muang, Chiang Mai 50200, Thailand

3Khon Kaen University Faculty of Medicine, Srinagarind Hospital, 123 Mittraphap Highway, Tambol Naimuang, Muang District, Khon Kaen 40002, Thailand

4Mahidol University Faculty of Medicine Ramathibodi Hospital, 270 Rama VI. Road, oong Phayathai, Ratchathewi, Bangkok 10400, Thailand

5GlaxoSmithKline Thailand, 12th Floor, Wave Place, 55 Wireless Road, Lumpini, Patumwan, Bangkok 10330, Thailand

6Hinduja Hospital and Medical Research Centre, Department of Microbiology, Veer Savarkar Marg, Mahim, Mumbai 400 016, India

7Choithram Hospital and Research Centre, Department of Microbiology, Manik Bagh Road, Indore 452 014 (M/P), India

8St John’s Medical College Hospital, Department of Microbiology, Sarjapur Road, Bangalore 560 034, India

9Christian Medical College, Department of Microbiology, Vellore 632 004, India

10GlaxoSmithKline India, No. 5 Embassy Links, Cunningham (SRT) Road, Bangalore 560 052, India

11The Catholic University of Korea, Seoul St Mary’s Hospital, 222 Banpo-daero, Seocho-Gu, Seoul, South Korea

12Yonsei University College of Medicine, Severance Hospital, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, South Korea

13Yonsei University College of Medicine, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul, South Korea

14Hanyang University Medical Center, 222-1, Wangsimni-ro, Seongdong-gu, Seoul, South Korea

15The Catholic University of Korea, Uijongbu St Mary’s Hospital, 271, Cheonbo-ro, Ukjeongbu-si, Gyeonggi-do, Korea

16GlaxoSmithKline Korea, LS Yongsan Tower, 9th Floor, Hangang 191, Yongsan-gu, Seoul, South Korea

17Changi General Hospital Pte Ltd (Reg. No. 198904226R), 2 Simei Street 3, Singapore 529889

18GlaxoSmithKline Singapore, (Reg. No. 198102938K), 150 Beach Road, No. 22-00 Gateway West, Singapore 189720

19IHMA Europe Sàrl, 9A Route de la Corniche, Epalinges 1066, Switzerland

Objectives

To provide susceptibility data for community-acquired respiratory tract isolates of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis collected in 2012–14 from four Asian countries.

Methods

MICs were determined using Etest® for all antibiotics except erythromycin, which was evaluated by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide/clindamycin interpretation, breakpoints were adjusted for incubation in CO2 where available.

Results

Susceptibility of S. pneumoniae was generally lower in South Korea than in other countries. Penicillin susceptibility assessed using CLSI oral or EUCAST breakpoints ranged from 21.2% in South Korea to 63.8% in Singapore. In contrast, susceptibility using CLSI intravenous breakpoints was much higher, at 79% in South Korea and 95% or higher elsewhere. Macrolide susceptibility was 20% in South Korea and 50%–60% elsewhere. Among S. pyogenes isolates (India only), erythromycin susceptibility (20%) was lowest of the antibiotics tested. In H. influenzae antibiotic susceptibility was high except for ampicillin, where susceptibility ranged from 16.7% in South Korea to 91.1% in India. South Korea also had a high percentage (18.1%) of β-lactamase-negative ampicillin-resistant isolates. Amoxicillin/clavulanic acid susceptibility for each pathogen (PK/PD high dose) was between 93% and 100% in all countries except for H. influenzae in South Korea (62.5%).

Conclusions

Use of EUCAST versus CLSI breakpoints had profound differences for cefaclor, cefuroxime and ofloxacin, with EUCAST showing lower susceptibility. There was considerable variability in susceptibility among countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.

PDF

http://jac.oxfordjournals.org/content/71/suppl_1/i3.full.pdf

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Epidemiología, Infecciones respiratorias, Metodos diagnosticos, Resistencia bacteriana.

Influenza vaccination of pregnant women and protection of their infants. Results from the Survey of Antibiotic Resistance (SOAR) 2011–14 in the Democratic Republic of Congo, Ivory Coast, Republic of Senegal and Kenya


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