Escherichia coli Harboring mcr-1 and blaCTX-M on a Novel IncF Plasmid: First report of 2 mcr-1 in the USA

May 30, 2016 at 8:38 am

Antimicrob. Agents Chemother. May 26, 2016

Patrick McGann1#*, Erik Snesrud1*, Rosslyn Maybank1 , Brendan Corey1 , Ana C. Ong1 3 , Robert Clifford1, Mary Hinkle1 , Timothy Whitman2 , Emil Lesho1 , and Kurt E. Schaecher3# 4

1 5 Multidrug-resistant Organism Repository and Surveillance Network, Walter Reed Army

6 Institute of Research, Silver Spring, Maryland, USA.

2 7 Department of Infectious Diseases, Walter Reed National Military Medical Center, MD, USA .

3 8 Department of Pathology, Walter Reed National Military Medical Center, MD, USA.

Patrick Mc Gann, PhD Walter Reed Army Institute of Research, 2S35 Silver Spring, Maryland 20910, USA Phone: (301) 319 9912 Email:

The recent discovery of a plasmid-borne colistin resistance gene, mcr-1, heralds the emergence of truly pan-drug resistant bacteria (1). The gene has been found primarily in Escherichia coli, but has also been identified in other members of the Enterobacteriaceae from human, animal, food and environmental samples on every continent (2-5). In response to this threat, starting in May 2016, all extended-spectrum β-lactamase (ESBL)-producing E.coli clinical isolates submitted to the clinical microbiology laboratory at the Walter Reed National Military Medical Center (WRNMMC) were tested for resistance to colistin by E-test. Herein we report the presence of mcr-1 in an E. coli cultured from a patient with a urinary tract infection (UTI) in the United States….


Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Epidemiología, Infecciones urinarias, Metodos diagnosticos, REPORTS, Resistencia bacteriana, Sepsis, Update. Tags: .

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