Zika Virus

June 15, 2016 at 3:31 pm

Clinical Microbiology Reviews July 2016 V.29 N.3 P.487-524


Didier Musso and Duane J. Gubler

aUnit of Emerging Infectious Diseases, Institut Louis Malardé, Tahiti, French Polynesia

bProgram in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore

cPartnership for Dengue Control, Lyon, France

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the family Flaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes.

The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya.

ZIKV infection was associated with only mild illness prior to the large French Polynesian outbreak in 2013 and 2014, when severe neurological complications were reported, and the emergence in Brazil of a dramatic increase in severe congenital malformations (microcephaly) suspected to be associated with ZIKV. Laboratory diagnosis of Zika fever relies on virus isolation or detection of ZIKV-specific RNA.

Serological diagnosis is complicated by cross-reactivity among members of the Flavivirus genus. The adaptation of ZIKV to an urban cycle involving humans and domestic mosquito vectors in tropical areas where dengue is endemic suggests that the incidence of ZIKV infections may be underestimated.

There is a high potential for ZIKV emergence in urban centers in the tropics that are infested with competent mosquito vectors such as Aedes aegypti and Aedes albopictus.




Entry filed under: Biología Molecular, Epidemiología, FIEBRE en el POST-VIAJE, Infecciones del SNC, Infecciones emergentes, Infecciones en embarzadas, Infecciones virales, Medicina del viajero, Metodos diagnosticos, REVIEWS, Sepsis, Update, Zoonosis.

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