Archive for June 29, 2016

Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea

N Engl J Med June 2016 V.374 P.2504-2506

CORRESPONDENCE

To the Editor:

Resistance to all antimicrobial agents has developed in some Neisseria gonorrhoeae strains. Dual antimicrobial therapy (ceftriaxone plus azithromycin) is a recommended first-line empirical treatment in many countries.1-3 We describe treatment failure with dual therapy in a patient with gonorrhea….

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http://www.nejm.org/doi/pdf/10.1056/NEJMc1512757

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June 29, 2016 at 3:36 pm

Management of Adult Syphilis

Clinical Infectious Diseases Dec.2011 V.53 N.12 Suppl.3  S110-S128

Khalil G. Ghanem1 and Kimberly A. Workowski2,3

1Johns Hopkins University School of Medicine, Baltimore, Maryland

2National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention

3Emory University, Atlanta, Georgia

There are several important unanswered key questions in the management of adult syphilis. A systematic literature review was conducted and tables of evidence were constructed to answer these important questions. A single dose of 2.4 million units of benzathine penicillin G remains the drug of choice for managing early syphilis. Enhanced antibiotic therapy has not been shown to improve treatment outcomes, regardless of human immunodeficiency virus (HIV) status. Although additional data on the efficacy of azithromycin in treating early syphilis have emerged, reported increases in the prevalence of a mutation associated with azithromycin resistance precludes a recommendation for its routine use. Cerebrospinal fluid (CSF) examination should be performed in all persons with serologic evidence of syphilis infection and neurologic symptoms. In those persons with early syphilis who do not achieve a ≥4-fold serologic decline in their rapid plasma reagin (RPR) titers 6–12 months after adequate therapy and those with late latent infection who do not achieve a similar decline within 12–24 months, CSF examination should be considered. Among HIV-infected persons, CSF examination among all those with asymptomatic late latent syphilis is not recommended owing to lack of evidence that demonstrates clinical benefit. HIV-infected persons with syphilis of any stages whose RPR titers are ≥1:32 and/or whose CD4 cell counts are <350 cells/mm3 may be at increased risk for asymptomatic neurosyphilis. If CSF pleocytosis is evident at initial CSF examination, these examinations should be repeated every 6 months until the cell count is normal. Several important questions regarding the management of syphilis remain unanswered and should be a priority for future research.

PDF

http://cid.oxfordjournals.org/content/53/suppl_3/S110.full.pdf+html

June 29, 2016 at 9:05 am

Sexually Transmitted Diseases in Men Who Have Sex With Men

Clinical Infectious Diseases Dec.2011 V.53 N.12 Suppl.3  S79-S83

Kenneth H. Mayer1,2

1Harvard Medical School, Beth Israel Deaconess Medical Center

2Fenway Institute, Fenway Health, Boston, Massachusetts

Men who have sex with men (MSM) have increased rates of human immunodeficiency virus (HIV) infection and sexually transmitted diseases (STDs) compared with demographically matched controls. The reasons for the disproportionate infection burden are complex, including biological, behavioral, and sociocultural factors. HIV and syphilis may often be coprevalent among MSM. The use of nucleic acid amplification testing has enhanced the ability to detect frequently asymptomatic gonococcal and chlamydial infections of the rectum and other sites. Lymphogranuloma proctitis outbreaks among MSM were noted in the developed world several years ago but have not been common recently. MSM are at increased risk for viral hepatitis and anal human papillomavirus disease. Preventive interventions include vaccination for the former and anal cytologic screening for the latter. Because of the diverse ways in which MSM may be exposed to STDs, it is essential for clinicians to obtain a thorough sexual history in a culturally competent manner.

PDF

http://cid.oxfordjournals.org/content/53/suppl_3/S79.full.pdf+html

June 29, 2016 at 9:03 am

Sexually Transmitted Infections Among Women Who Have Sex With Women

Clinical Infectious Diseases Dec.2011 V.53 N.12 Suppl.3  S84-S91

Linda M. Gorgos1 and Jeanne M. Marrazzo2

1Infectious Disease Bureau, Public Health Division, New Mexico Department of Health, Santa Fe

2Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle

Women who have sex with women (WSW) are a diverse group with variations in sexual identity, sexual behaviors, sexual practices, and risk behaviors. WSW are at risk of acquiring bacterial, viral, and protozoal sexually transmitted infections (STIs) from current and prior partners, both male and female. Bacterial vaginosis is common among women in general and even more so among women with female partners. WSW should not be presumed to be at low or no risk for STIs based on sexual orientation, and reporting of same-sex behavior by women should not deter providers from considering and performing screening for STIs, including chlamydia, in their clients according to current guidelines. Effective delivery of sexual health services to WSW requires a comprehensive and open discussion of sexual and behavioral risks, beyond sexual identity, between care providers and their female clients.

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http://cid.oxfordjournals.org/content/53/suppl_3/S84.full.pdf+html

June 29, 2016 at 9:01 am


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