Structural basis of potent Zika–dengue virus antibody cross-neutralization.

July 7, 2016 at 7:52 am

Nature 2016 Jun 23; [e-pub]

Barba-Spaeth G et al

Institut Pasteur, Unité de Virologie Structurale, Département de Virologie, F-75724 Paris Cedex 15, France

Giovanna Barba-Spaeth, Alexander Rouvinski, Marie-Christine Vaney, Arvind Sharma & Félix A. Rey

CNRS UMR 3569 Virologie, F-75724 Paris Cedex 15, France

Giovanna Barba-Spaeth, Alexander Rouvinski, Marie-Christine Vaney, Arvind Sharma & Félix A. Rey

Division of Immunology and Inflammation, Department of Medicine, Hammersmith campus, Imperial College London, UK

Wanwisa Dejnirattisai, Juthathip Mongkolsapaya & Gavin R. Screaton

Department of Virology, Medical University of Vienna, Kinderspitalgasse 15, A-1095 Vienna, Austria

Iris Medits, Karin Stiasny & Franz X. Heinz

Institut Pasteur, Unité de Génétique fonctionnelle des maladies infectieuses, Département de Génomes et Génétique, F-75724 Paris Cedex 15, France

Etienne Simon-Lorière & Anavaj Sakuntabhai

CNRS URA 3012, F-75724 Paris Cedex 15, France

Etienne Simon-Lorière & Anavaj Sakuntabhai

Unit of Emerging Infectious Diseases, Institut Louis Malardé, Papeete,Tahiti,French Polynesia

Van-Mai Cao-Lormeau

Institut Pasteur, Plateforme de Cristallographie, Département de Biologie Structurale et Chimie, F-75724 Paris Cedex 15, France

Ahmed Haouz

Institut Pasteur, Plateforme de Biophysique des Macromolécules et de leurs Interactions, Département de Biologie Structurale et Chimie, F-75724 Paris Cedex 15, France

Patrick England

Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand

Juthathip Mongkolsapaya

Zika virus is a member of the flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and we report here that a category of antibodies isolated from dengue patients and targeting a conformational epitope potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor prM protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect against Zika and dengue viruses simultaneously

abstract

http://www.nature.com/nature/journal/vaap/ncurrent/full/nature18938.html

PDF

http://www.nature.com/nature/journal/vaap/ncurrent/pdf/nature18938.pdf

Entry filed under: Biología Molecular, Epidemiología, Infecciones emergentes, Inmunizaciones, Medicina del viajero, Update. Tags: .

REVISION – IV CONSENSO ERRADICACION H pylorii Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus


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