Editor’s Choice: Transferable resistance to colistin: a new but old threat

July 24, 2016 at 12:30 pm

Journal of Antimicrobial Chemotherapy August 2016 V.71 N.8  P.2066-2070

Stefan Schwarz and Alan P. Johnson

1Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Neustadt-Mariensee, Germany

2Department of Healthcare-Associated Infection and Antimicrobial Resistance, National Infection Service, Public Health England, London NW9 5EQ, UK

In this Leading article, we summarize current knowledge of the occurrence of the first and so far only transferable colistin resistance gene, mcr-1. Its location on a conjugative plasmid is likely to have driven its spread into a range of enteric bacteria in humans and animals. Screening studies have identified mcr-1 in five of the seven continents and retrospective studies in China have identified this gene in Escherichia coli originally isolated in the 1980s, while the first European isolate dates back to 2005. Based on the widespread use of colistin in pigs and poultry in several countries and the higher number of mcr-1-carrying isolates of animal origin than of human origin, it is tempting to assume that this resistance may have emerged in the animal sector. Whatever its origin, interventions to reduce its further spread will require an integrated global one-health approach, comprising robust antibiotic stewardship to reduce unnecessary colistin use, improved infection prevention, and control and surveillance of colistin usage and resistance in both veterinary and human medicine.

The mcr-1 gene encoding colistin resistance in Escherichia coli has been around since the 1980s, appears to be ubiquitous and may have emerged in the animal sector, but interventions to reduce its further spread will require an integrated global one-health approach.




Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Resistencia bacteriana, Sepsis, Update.

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