Strategies for targeting residual HIV infection
Current Opinion In HIV and AIDS July 2016 V.11 N.4 P.359–361
Chomont, Nicolas; Perreau, Matthieu
aCentre de Recherche du CHUM
bDepartment of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montréal, Quebec, Canada
cDivision of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
Seven years ago, Hutter et al. reported the unique case of a 40-year-old HIV-infected man who was cured of HIV infection following an allogeneic bone marrow transplant. Timothy Ray Brown, also known as the ‘Berlin Patient’ is until today the only person from whom HIV has been eradicated. This extraordinary and largely unexpected success fostered HIV cure research by opening novel therapeutic possibilities that could potentially surpass combination antiretroviral therapy (ART). Indeed, although ART has dramatically reduced the death rate from AIDS and improved the quality of life of many HIV-infected individuals, the possible long-term toxicity associated with ART, stigma and cost all contribute to the necessity of finding a cure….
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