ATB PROPHYLAXIS IN BARIATRIC SURGERY – Continuous infusion of cefazolin vs ampicillin/sulbactam and ertapenem

August 20, 2016 at 4:31 pm

Arq Gastroenterol. 2015 Apr-Jun;52(2):83-7.

Ferraz ÁA1, Siqueira LT1, Campos JM1, Araújo GC1, Martins Filho ED1, Ferraz EM1.

Author information

1Department of Surgery, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brasil.

Abstract

BACKGROUND:

The incidence of surgical site infection in bariatric patients is significant and the current recommendations for antibiotic prophylaxis are sometimes inadequate. Objective: The aim of this study was to analyze the effect of three prophylactic antibiotic regimens on the incidence of surgical site infection.

METHODS:

A prospective, cross-sectional study was conducted between January 2009 and January 2013 in which 896 Roux-en-Y gastric bypasses were performed to treat obesity. The study compared three groups of patients according to the perioperative antibiotic prophylaxis administered intravenously and beginning at anesthesia induction: Group I consisting of 194 patients treated with two 3-g doses of ampicillin/sulbactam; Group II with 303 patients treated with a single 1-g dose of ertapenem; and Group III with 399 patients treated with a 2-g dose of cefazolin at anesthesia induction followed by a continuous infusion of cefazolin 1g throughout the surgical procedure. The rate of surgical site infection was analyzed, as well as its association with age, sex, preoperative weight, body mass index and comorbidities.

RESULTS:

The rates of surgical site infection were 4.16% in the group treated prophylactically with ampicillin/sulbactam, 1.98% in the ertapenem group and 1.55% in the continuous cefazolin group.

CONCLUSION:

The prophylactic use of continuous cefazolin in surgeries for morbid obesity shows very promising results. These findings suggest that some prophylactic regimens need to be reconsidered and even substituted by more effective therapies for the prevention of surgical site infections in bariatric patients.

PDF

http://www.scielo.br/pdf/ag/v52n2/0004-2803-ag-52-02-83.pdf

Entry filed under: Antimicrobianos, Bacterias, Infecciones y Obesidad, Profilaxis Antibiótica en Cirugía - PAC, REPORTS, Resistencia bacteriana, Update. Tags: .

Daptomycin dosing greater than 6 mg/kg/day depending on pharmacokinetic and pharmacodynamic parameters infections by Staph aureus. Population Pharmacokinetics and Target Attainment of Meropenem in Plasma and Tissue of Morbidly Obese Patients after Laparoscopic Intraperitoneal Surgery.


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