Daptomycin dosing greater than 6 mg/kg/day depending on pharmacokinetic and pharmacodynamic parameters infections by Staph aureus.

August 20, 2016 at 4:29 pm

Farm Hosp. 2013 Nov-Dec;37(6):534-8.

Article in Spanish

Gutiérrez Urbón JM1, Linares Mondéjar P, Martin Herranz I.

Author information

1Servicio de Farmacia. Complejo Hospitalario Universitario. A Coruña.

Abstractin English, Spanish

Daptomycin is a cyclic lipopeptide antibiotic whose approved dose is 4 to 6 mg/kg/day. Today it is a matter of controversy the use of higher doses of daptomycin in a range of 8-12 mg/kg/ day, for the treatment of Staphylococcus aureus infections, justified by its concentration-dependent action and its tolerability and safety profile, but the available studies are inconclusive. Stratification is performed by groups of patients, on the recommendation of using doses above 6 mg/kg/day based on the PK/PD parameters predictive of efficacy and safety. We conclude that doses of 8-12 mg/kg/day may be beneficial in patients with severe sepsis, patients with hypoalbuminemia and infections involving potentially high bacterial load or where there is a bacterial kidnapping. However it is not suitable exceed the dose of 6 mg/kg/day in patients with obesity and/or creatinine clearance less than 50 ml/min

PDF

http://www.grupoaulamedica.com/fh/pdf/742.pdf

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Infecciones y Obesidad, Metodos diagnosticos, Resistencia bacteriana, Sepsis, Update. Tags: .

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