Staphylococcus aureus Toxins and Diabetic Foot Ulcers: Role in Pathogenesis and Interest in Diagnosis.

October 20, 2016 at 3:25 pm

Toxins (Basel). 2016 Jul 7;8(7).

Dunyach-Remy C1,2, Ngba Essebe C3, Sotto A4,5, Lavigne JP6,7.

Author information

1Institut National de la Santé Et de la Recherche Médicale U1047, Université de Montpellier, UFR de Médecine, Nîmes 30908, France. catherine.remy@chu-nimes.fr

2Service de Microbiologie, Centre Hospitalo-Universitaire Carémeau, Nîmes 30029, France. catherine.remy@chu-nimes.fr

3Institut National de la Santé Et de la Recherche Médicale U1047, Université de Montpellier, UFR de Médecine, Nîmes 30908, France. ngbachristelle@hotmail.fr

4Institut National de la Santé Et de la Recherche Médicale U1047, Université de Montpellier, UFR de Médecine, Nîmes 30908, France. albert.sotto@chu-nimes.fr

5Service des Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire Carémeau, Nîmes 30029, France. albert.sotto@chu-nimes.fr

6Institut National de la Santé Et de la Recherche Médicale U1047, Université de Montpellier, UFR de Médecine, Nîmes 30908, France. jean.philippe.lavigne@chu-nimes.fr

7Service de Microbiologie, Centre Hospitalo-Universitaire Carémeau, Nîmes 30029, France. jean.philippe.lavigne@chu-nimes.fr

Abstract

Infection of foot ulcers is a common, often severe and costly complication in diabetes.

Diabetic foot infections (DFI) are mainly polymicrobial, and Staphylococcus aureus is the most frequent pathogen isolated.

The numerous virulence factors and toxins produced by S. aureus during an infection are well characterized. However, some particular features could be observed in DFI.

The aim of this review is to describe the role of S. aureus in DFI and the implication of its toxins in the establishment of the infection.

Studies on this issue have helped to distinguish two S. aureus populations in DFI: toxinogenic S. aureus strains (harboring exfoliatin-, EDIN-, PVL- or TSST-encoding genes) and non-toxinogenic strains.

Toxinogenic strains are often present in infections with a more severe grade and systemic impact, whereas non-toxinogenic strains seem to remain localized in deep structures and bone involving diabetic foot osteomyelitis.

Testing the virulence profile of bacteria seems to be a promising way to predict the behavior of S. aureus in the chronic wounds.

PDF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963842/pdf/toxins-08-00209.pdf

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Epidemiología, Infecciones en diabeticos, Infecciones en piel y tej blandos, Infecciones osteo-articulares-musculares, Metodos diagnosticos, Resistencia bacteriana, REVIEWS, Sepsis, Update. Tags: .

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