Laboratory Diagnosis of Congenital Toxoplasmosis

October 30, 2016 at 12:04 pm

Journal of Clinical Microbiology October 2016 V.54 N.10 P.2448-2454

Christelle Pomares and Jose G. Montoya

aPalo Alto Medical Foundation Toxoplasma Serology Laboratory, National Reference Center for the Study and Diagnosis of Toxoplasmosis, Palo Alto, California, USA

bStanford University, Division of Infectious Diseases, Stanford, California, USA

cINSERM U1065, Centre Méditerranéen de Médecine Moléculaire, Toxines Microbiennes dans la Relation Hôte-Pathogènes, Nice, France

dService de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Nice, Nice, France

Recent studies have demonstrated that screening and treatment for toxoplasmosis during gestation result in a decrease of vertical transmission and clinical sequelae. Early treatment was associated with improved outcomes.

Thus, laboratory methods should aim for early identification of infants with congenital toxoplasmosis (CT). Diagnostic approaches should include, at least, detection of Toxoplasma IgG, IgM, and IgA and a comprehensive review of maternal history, including the gestational age at which the mother was infected and treatment.

Here, we review laboratory methods for the diagnosis of CT, with emphasis on serological tools. A diagnostic algorithm that takes into account maternal history is presented

PDF

http://jcm.asm.org/content/54/10/2448.full.pdf+html

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Entry filed under: Biología Molecular, Epidemiología, Infecciones parasitarias, Metodos diagnosticos, REVIEWS, Sepsis, Update.

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