Laboratory Diagnosis of Congenital Toxoplasmosis
Journal of Clinical Microbiology October 2016 V.54 N.10 P.2448-2454
Christelle Pomares and Jose G. Montoya
aPalo Alto Medical Foundation Toxoplasma Serology Laboratory, National Reference Center for the Study and Diagnosis of Toxoplasmosis, Palo Alto, California, USA
bStanford University, Division of Infectious Diseases, Stanford, California, USA
cINSERM U1065, Centre Méditerranéen de Médecine Moléculaire, Toxines Microbiennes dans la Relation Hôte-Pathogènes, Nice, France
dService de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Nice, Nice, France
Recent studies have demonstrated that screening and treatment for toxoplasmosis during gestation result in a decrease of vertical transmission and clinical sequelae. Early treatment was associated with improved outcomes.
Thus, laboratory methods should aim for early identification of infants with congenital toxoplasmosis (CT). Diagnostic approaches should include, at least, detection of Toxoplasma IgG, IgM, and IgA and a comprehensive review of maternal history, including the gestational age at which the mother was infected and treatment.
Here, we review laboratory methods for the diagnosis of CT, with emphasis on serological tools. A diagnostic algorithm that takes into account maternal history is presented