Guillain–Barré Syndrome Associated with Zika Virus Infection in Colombia

November 14, 2016 at 7:54 am

N Engl J of Medicine October 26, 2016 V.375 N. P.1513-1523

Beatriz Parra, Ph.D., Jairo Lizarazo, M.D., Jorge A. Jiménez-Arango, M.D., Andrés F. Zea-Vera, M.D., Ph.D., Guillermo González-Manrique, M.D., José Vargas, M.D., Jorge A. Angarita, M.D., Gonzalo Zuñiga, M.D., Reydmar Lopez-Gonzalez, M.D., Cindy L. Beltran, M.D., Karen H. Rizcala, M.D., Maria T. Morales, M.D., Oscar Pacheco, M.D., Martha L. Ospina, M.D., Anupama Kumar, M.B., B.S., David R. Cornblath, M.D., Laura S. Muñoz, M.D., Lyda Osorio, M.D., Ph.D., Paula Barreras, M.D., and Carlos A. Pardo, M.D.

Zika virus (ZIKV), a mosquito-borne RNA flavivirus, has caused a major outbreak in the Americas that began in 2014.1 ZIKV infection manifests as a self-limited febrile syndrome associated with rash, conjunctivitis, and arthralgias.2-4 In 2013 and 2014, an increase in the number of cases of the Guillain–Barré syndrome was observed during an outbreak of ZIKV infection in French Polynesia.5,6 Recently, clusters of the Guillain–Barré syndrome and microcephaly have been spatially and temporally related to the current outbreak of ZIKV infection in the Americas.7 In Colombia, the government reported the first autochthonous case of ZIKV infection in October 2015.8 In December 2015, the Colombian Instituto Nacional de Salud (INS) documented an unusual number of cases of the Guillain–Barré syndrome in the Caribbean and the northeastern regions of Colombia. By January 2016, the outbreak of ZIKV infection had spread to most regions of Colombia. Concomitantly, an increase in the number of neuroinflammatory disorders was reported.7 Here, we describe an observational clinical and virologic study of the Guillain–Barré syndrome cases that were evaluated in the context of the ZIKV outbreak in Colombia, which further supports the association between ZIKV infection and the Guillain–Barré syndrome — in particular, the acute inflammatory demyelinating polyneuropathy (AIDP) form of the syndrome …

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http://www.nejm.org/doi/pdf/10.1056/NEJMoa1605564

Entry filed under: Biología Molecular, Epidemiología, F.O.D, FIEBRE y RASH, Infecciones del SNC, Infecciones emergentes, Infecciones en embarzadas, Infecciones virales, Medicina del viajero, Metodos diagnosticos, REPORTS, Sepsis, Update, Zoonosis. Tags: .

Primer caso confirmado de síndrome congénito asociado a la infección por el virus Zika en Tucumán (Argentina) Core Elements of Outpatient Antibiotic Stewardship


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