Comment – More pieces to the microcephaly–Zika virus puzzle in Brazil

November 15, 2016 at 12:14 pm

Lancet Infectious Diseases December 2016 V.16 N.12 P.1307–1309

Patricia Brasil, Karin Nielsen-Saines

By October, 2015, the Zika virus epidemic had grown substantially in Brazil with 14 states reporting autochthonous Zika virus transmission. Concurrently, concerns were raised regarding the discovery of a substantial increase in the number of microcephaly cases, particularly in the state of Pernambuco. The following month, a national public health emergency was declared in Brazil in response to growing concerns about the potential association between Zika virus and newborn microcephaly, with 1248 reported cases—20 times greater than the expected number.1 Following this announcement, additional progress was made in establishing more definitive associations between Zika virus and congenital anomalies, including microcephaly.2, 3

Studies in mouse models have addressed the causal relation between Zika virus infection in pregnancy and pathological changes in fetuses.4, 5 Although a growing body of evidence suggests that Zika virus causes brain anomalies and microcephaly, describing what has been identified as congenital Zika virus infection syndrome, there is a paucity of published prospective epidemiological studies.3 A study by Thalia Araújo and colleagues6 in The Lancet Infectious Diseases might be a missing piece to the puzzle, providing necessary epidemiological data to further advance our understanding of the association….

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http://www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(16)30372-3.pdf

Entry filed under: Biología Molecular, Epidemiología, FIEBRE en el POST-VIAJE, Infecciones del SNC, Infecciones emergentes, Infecciones virales, Medicina del viajero, Metodos diagnosticos, Sepsis, Update, Zoonosis. Tags: .

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