Methicillin-Resistant Staphylococcus aureus CC398 in Humans and Pigs in Norway: A “One Health” Perspective on Introduction and Transmission

November 15, 2016 at 10:50 pm

Clinical Infectious Diseases December 1, 2016 V.63 N.11 P.1431-1438

Carl Andreas Grøntvedt, Petter Elstrøm, Marc Stegger, Robert Leo Skov, Paal Skytt Andersen, Kjersti Wik Larssen, Anne Margrete Urdahl, Øystein Angen, Jesper Larsen, Solfrid Åmdal, Siri Margrete Løtvedt, Marianne Sunde, and Jørgen Vildershøj Bjørnholt

1The Norwegian Veterinary Institute

2The Norwegian Institute of Public Health, Oslo

3St Olavs Hospital, The Norwegian Reference Laboratory for MRSA, Trondheim

4The Norwegian Food Safety Authority, Brumunddal

5Statens Serum Institut, Copenhagen, Denmark

6Pathogen Genomics Division, Translational Genomics Research Institute (TGen), Flagstaff, Arizona

Background

Emerging livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) persist in livestock populations and represent a reservoir for transmission to humans. Understanding the routes of introduction and further transmission is crucial to control this threat to human health.

Methods

All reported cases of livestock-associated MRSA (CC398) in humans and pigs in Norway between 2008 and 2014 were included. Data were collected during an extensive outbreak investigation, including contact tracing and stringent surveillance. Whole-genome sequencing of isolates from all human cases and pig farms was performed to support and expand the epidemiological findings. The national strategy furthermore included a “search-and-destroy” policy at the pig farm level.

Results

Three outbreak clusters were identified, including 26 pig farms, 2 slaughterhouses, and 36 humans. Primary introductions likely occurred by human transmission to 3 sow farms with secondary transmission to other pig farms, mainly through animal trade and to a lesser extent via humans or livestock trucks. All MRSA CC398 isolated from humans without an epidemiological link to the outbreaks were genetically distinct from isolates within the outbreak clusters indicating limited dissemination to the general population.

Conclusions

This study identified preventable routes of MRSA CC398 introduction and transmission: human occupational exposure, trade of pigs and livestock transport vehicles. These findings are essential for keeping pig populations MRSA free and, from a “One Health” perspective, preventing pig farms from becoming reservoirs for MRSA transmission to humans.

PDF

https://cid.oxfordjournals.org/content/63/11/1431.full.pdf+html

Entry filed under: Bacterias, Bacteriemias, Antimicrobianos, Resistencia bacteriana, Metodos diagnosticos, Sepsis, Epidemiología, REPORTS, Update, Biología Molecular. Tags: .

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